| Literature DB >> 19818769 |
Christopher A Ingraham1, Nina F Schor.
Abstract
The neurotrophin receptor p75NTR provides protection from oxidant stress induced by 6-hydroxydopamine (6-OHDA) and resultant cell death. In the absence of p75NTR, TrkA is upregulated and its signaling pathway effectors are increasingly activated. Necdin, a MAGE protein and known interactor of p75NTR and TrkA, is a potential mediator of this phenomenon. Decreased expression of necdin protein in p75NTR-deficient PC12 cells decreased TrkA expression and increased PC12 cell resistance to 6-OHDA. Inhibition of JNK phosphorylation by SP600125 also resulted in increased resistance to 6-OHDA, suggesting that TrkA signaling underlies the susceptibility of these cells to oxidant stress.Entities:
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Year: 2009 PMID： 19818769 PMCID： PMC2788019 DOI： 10.1016/j.yexcr.2009.10.001
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905