Literature DB >> 19818613

Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.

Christopher S Burgey1, Craig M Potteiger, James Z Deng, Scott D Mosser, Christopher A Salvatore, Sean Yu, Shane Roller, Stefanie A Kane, Joseph P Vacca, Theresa M Williams.   

Abstract

Several novel spiropiperidine-based CGRP receptor antagonists have been developed that maintain good potency and have reduced potential for metabolism.

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Year:  2009        PMID： 19818613     DOI： 10.1016/j.bmcl.2009.09.066

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine.

Authors:  Paul L Durham; Carrie V Vause
Journal:  CNS Drugs       Date:  2010-07       Impact factor: 5.749

2.  Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compounds.

Authors:  Hao Zhou; Xin Che; Guochen Bao; Na Wang; Li Peng; Kimberly D Barnash; Stephen V Frye; Lindsey I James; Xu Bai
Journal:  Bioorg Med Chem Lett       Date:  2016-08-03       Impact factor: 2.823
  2 in total

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