| Literature DB >> 19818611 |
Ronald Palin1, John K Clark, Louise Evans, Helen Feilden, Dan Fletcher, Niall M Hamilton, Andrea K Houghton, Philip S Jones, Duncan McArthur, Brian Montgomery, Paul D Ratcliffe, Alasdair R C Smith, Aaron Sutherland, Mark A Weston, Grant Wishart.
Abstract
A knowledge based approach has been adopted to identify novel NOP receptor agonists with simplified hydrophobes. Substitution of the benzimidazol-2-one piperidine motif with a range of hydrophobic groups and pharmacophore guided bio-isosteric replacement of the benzimidazol-2-one moiety was explored. Compound 51 was found to be a high affinity, potent NOP receptor agonist with reduced affinity for the hERG channel.Entities:
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Year: 2009 PMID： 19818611 DOI： 10.1016/j.bmcl.2009.09.028
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823