| Literature DB >> 19818400 |
Abstract
The work described here continues our studies of the effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus. Mitomycin C and the new-generation fluoroquinolone moxifloxacin induced expression of SOS response genes (lexA, recA, sosA, and umuC) in a ciprofloxacin-resistant Cip(r)I strain of S. aureus. To examine phenotypic changes in Cip(r) strains mutated in CIP targets (GrlA and/or GyrA), we used Biolog Phenotype MicroArrays. Two other Cip(r) strains mutated in the norA promoter region were used to study the effects of subinhibitory concentrations of DNA-damaging antibiotics on norA expression. We show that mitomycin C and moxifloxacin induced overexpression of the norA gene in Cip(r) strains. Finally, we confirm that subinhibitory concentrations of CIP increase mutation rates in S. aureus.Entities:
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Year: 2009 PMID： 19818400 DOI： 10.1016/j.resmic.2009.09.013
Source DB: PubMed Journal: Res Microbiol ISSN： 0923-2508 Impact factor: 3.992