BACKGROUND: Recent studies have demonstrated that statins may possess anti-arrhythmic properties in addition to their lipid-lowering effects. METHODS: Studies which reported the association of statins with the incidence of ventricular arrhythmias were identified through a systematic review of the published literature. RESULTS: Statins have been associated with a significant reductions in ventricular arrhythmia in cardiomyopathy patients with an implantable cardioverter defibrillator, although randomized trials have not been completed. CONCLUSIONS: Published data suggests that statins may possess anti-arrhythmic properties that reduce the propensity for ventricular arrhythmias. Most of this data is observational; more randomized, placebo-controlled trials are needed.
BACKGROUND: Recent studies have demonstrated that statins may possess anti-arrhythmic properties in addition to their lipid-lowering effects. METHODS: Studies which reported the association of statins with the incidence of ventricular arrhythmias were identified through a systematic review of the published literature. RESULTS: Statins have been associated with a significant reductions in ventricular arrhythmia in cardiomyopathypatients with an implantable cardioverter defibrillator, although randomized trials have not been completed. CONCLUSIONS: Published data suggests that statins may possess anti-arrhythmic properties that reduce the propensity for ventricular arrhythmias. Most of this data is observational; more randomized, placebo-controlled trials are needed.
Authors: Katarina Andelova; Barbara Szeiffova Bacova; Matus Sykora; Peter Hlivak; Miroslav Barancik; Narcis Tribulova Journal: Int J Mol Sci Date: 2022-01-26 Impact factor: 5.923