PURPOSE: Pancreatic cancer has been a serious disease worldwide for its high mortality. Cucurbitacin E is a member of triterpenoid family isolated from plants showing antiproliferative activity on various cancer cells. In this study, we have explored whether cucurbitacin E also has an anti-tumor effect on pancreatic cancer cells. METHODS: Human pancreatic cancer cells PANC-1 were used to explore the effect and possible mechanisms of cucurbitacin E on cell cycle progression, apoptosis and proliferation. RESULTS: Cucurbitacin E has inhibited the growth of PANC-1 cells in a dose- and time-dependent manner, and has caused accumulation of cells at the G(2)/M phase as well as apoptosis. Western blotting also showed that cucurbitacin E treatment can inhibit STAT3 phosphorylation while upregulate p53 expression. CONCLUSIONS: Our results suggested that cucurbitacin E may be an effective regimen for the chemotherapy of pancreatic cancer.
PURPOSE:Pancreatic cancer has been a serious disease worldwide for its high mortality. Cucurbitacin E is a member of triterpenoid family isolated from plants showing antiproliferative activity on various cancer cells. In this study, we have explored whether cucurbitacin E also has an anti-tumor effect on pancreatic cancer cells. METHODS:Humanpancreatic cancer cells PANC-1 were used to explore the effect and possible mechanisms of cucurbitacin E on cell cycle progression, apoptosis and proliferation. RESULTS:Cucurbitacin E has inhibited the growth of PANC-1 cells in a dose- and time-dependent manner, and has caused accumulation of cells at the G(2)/M phase as well as apoptosis. Western blotting also showed that cucurbitacin E treatment can inhibit STAT3 phosphorylation while upregulate p53 expression. CONCLUSIONS: Our results suggested that cucurbitacin E may be an effective regimen for the chemotherapy of pancreatic cancer.
Authors: Guilian Niu; Kenneth L Wright; Yihong Ma; Gabriela M Wright; Mei Huang; Rosalyn Irby; Jon Briggs; James Karras; W Douglas Cress; Drew Pardoll; Richard Jove; Jiangdong Chen; Hua Yu Journal: Mol Cell Biol Date: 2005-09 Impact factor: 4.272
Authors: Sin Ting Lau; Zhi-Xiu Lin; Yonghong Liao; Ming Zhao; Christopher H K Cheng; Po Sing Leung Journal: Cancer Lett Date: 2009-03-14 Impact factor: 8.679
Authors: Sarah Peisl; Claudia Mellenthin; Lucie Vignot; Carmen Gonelle-Gispert; Leo Bühler; Bernhard Egger Journal: PLoS One Date: 2021-06-17 Impact factor: 3.240