| Literature DB >> 19816702 |
Abrahan Hernández-Hernández1, Rosario Ortiz, Ernestina Ubaldo, Olga M Echeverría Martínez, Gerardo H Vázquez-Nin, Félix Recillas-Targa.
Abstract
The synaptonemal complex (SC) is the central key structure for meiosis in organisms undergoing sexual reproduction. During meiotic prophase I, homologous chromosomes exchange genetic information at the time they are attached to the lateral elements by specific DNA sequences. Most of these sequences, so far identified, consist of repeat DNA, which are subject to chromatin structural changes during meiotic prophase I. In this work, we addressed the effect of altering the chromatin structure of repeat DNA sequences mediating anchorage to the lateral elements of the SC. Administration of the histone deacetylase inhibitor trichostatin A into live rats caused death of cells in the pachytene stage as well as changes in histone marks along the synaptonemal complex. The most notable effect was partial loss of histone H3 lysine 27 trimethylation. Our work describes the epigenetic landscape of lateral element-associated chromatin and reveals a critical role of histone marks in synaptonemal complex integrity.Entities:
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Year: 2009 PMID： 19816702 DOI： 10.1007/s00412-009-0243-3
Source DB: PubMed Journal: Chromosoma ISSN： 0009-5915 Impact factor: 4.316