| Literature DB >> 19816666 |
Satoshi Horino1, Takeshi Rikiishi2, Hidetaka Niizuma2, Hiroshi Abe2, Yuko Watanabe2, Masaei Onuma2, Yoshiyuki Hoshi2, Yoji Sasahara2, Miyako Yoshinari2, Takuro Kazama3, Yutaka Hayashi3, Satoru Kumaki2, Shigeru Tsuchiya2.
Abstract
Immune thrombocytopenic purpura (ITP) has been associated with several hematologic malignancies such as Hodgkin and non-Hodgkin lymphomas and chronic lymphocytic leukemia, but it is rare in children with acute lymphoblastic leukemia (ALL). Here, we report a 7-year-old girl with chronic ITP during early intensive phase of chemotherapy for ALL. She underwent splenectomy because thrombocytopenia had persisted even after treatment with intravenous immunoglobulin (IVIG), steroids, vincristine, rituximab, and anti-D antibody. After splenectomy, her platelet count had recovered, and maintenance therapy could be resumed with a support of IVIG. To our knowledge, this is the first child case of chronic ITP during chemotherapy for ALL and splenectomy was effective in this patient.Entities:
Mesh：
Year: 2009 PMID： 19816666 DOI： 10.1007/s12185-009-0424-0
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490