OBJECTIVE: To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats. METHODS: Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by gavage at 125 microg genistein/g body weight/day, with a soy-free diet. Average numbers of nuclei (NU), blood vessels (BV) and collagen fibers (CF) in uterus and mid-urethra sections were compared using Dunnett and Tukey tests (95% CI). RESULTS: Uterus: GII and GIII differed from GI in all respects; GII vs. GIII, no differences. Urethra: GIII vs. GI: no differences; GII vs. GI, differences in NU and CF; GII vs. GIII, differences in NU and CF. CONCLUSIONS: Early oral administration of SIE to ovariectomized rats reversed uterine/urethral effects of castration.
OBJECTIVE: To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats. METHODS: Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by gavage at 125 microg genistein/g body weight/day, with a soy-free diet. Average numbers of nuclei (NU), blood vessels (BV) and collagen fibers (CF) in uterus and mid-urethra sections were compared using Dunnett and Tukey tests (95% CI). RESULTS: Uterus: GII and GIII differed from GI in all respects; GII vs. GIII, no differences. Urethra: GIII vs. GI: no differences; GII vs. GI, differences in NU and CF; GII vs. GIII, differences in NU and CF. CONCLUSIONS: Early oral administration of SIE to ovariectomized rats reversed uterine/urethral effects of castration.
Authors: K Morito; T Hirose; J Kinjo; T Hirakawa; M Okawa; T Nohara; S Ogawa; S Inoue; M Muramatsu; Y Masamune Journal: Biol Pharm Bull Date: 2001-04 Impact factor: 2.233
Authors: C Picherit; B Chanteranne; C Bennetau-Pelissero; M J Davicco; P Lebecque; J P Barlet; V Coxam Journal: Br J Nutr Date: 2001-03 Impact factor: 3.718
Authors: Y Ishimi; N Arai; X Wang; J Wu; K Umegaki; C Miyaura; A Takeda; S Ikegami Journal: Biochem Biophys Res Commun Date: 2000-08-11 Impact factor: 3.575
Authors: M J de Kleijn; Y T van der Schouw; P W Wilson; H Adlercreutz; W Mazur; D E Grobbee; P F Jacques Journal: J Nutr Date: 2001-06 Impact factor: 4.798