BACKGROUND AND AIMS: This study aimed to investigate the association of intraocular pressure (IOP) with the metabolic syndrome and other emerging cardiometabolic risk factors. METHODS: A total of 1112 participants undergoing a health check-up in a community hospital were recruited. All participants underwent ophthalmological examination including IOP measurement. RESULTS: Participants with metabolic syndrome had significantly higher IOP than those without metabolic syndrome (mean IOP+/-SD: 15.07+/-2.74 vs 14.29+/-2.72 mm Hg, P=2x10(-4)). Each additional component of the metabolic syndrome was associated with a mean increase in IOP of 0.33 mm Hg (95% confidence interval: 0.18-0.48, trend P<0.0001). Other insulin resistance-related features, including hepatic steatosis, increased left ventricular mass, and proteinuria, were also associated with IOP (P<0.0001, 0.002, and 0.01, respectively). However, we did not find significant association of plasma apolipoprotein A, apolipoprotein B1, homocysteine, or highly sensitive C-reactive protein levels with IOP. IOP was also not associated with measures of subclinical atherosclerosis including brachial-ankle pulse wave velocity, ankle-brachial index, and vertebral artery flow. CONCLUSION: Metabolic syndrome and other insulin resistance-related features, including hepatic steatosis, increased left ventricular mass, and proteinuria, are strongly associated with IOP.
BACKGROUND AND AIMS: This study aimed to investigate the association of intraocular pressure (IOP) with the metabolic syndrome and other emerging cardiometabolic risk factors. METHODS: A total of 1112 participants undergoing a health check-up in a community hospital were recruited. All participants underwent ophthalmological examination including IOP measurement. RESULTS:Participants with metabolic syndrome had significantly higher IOP than those without metabolic syndrome (mean IOP+/-SD: 15.07+/-2.74 vs 14.29+/-2.72 mm Hg, P=2x10(-4)). Each additional component of the metabolic syndrome was associated with a mean increase in IOP of 0.33 mm Hg (95% confidence interval: 0.18-0.48, trend P<0.0001). Other insulin resistance-related features, including hepatic steatosis, increased left ventricular mass, and proteinuria, were also associated with IOP (P<0.0001, 0.002, and 0.01, respectively). However, we did not find significant association of plasma apolipoprotein A, apolipoprotein B1, homocysteine, or highly sensitive C-reactive protein levels with IOP. IOP was also not associated with measures of subclinical atherosclerosis including brachial-ankle pulse wave velocity, ankle-brachial index, and vertebral artery flow. CONCLUSION:Metabolic syndrome and other insulin resistance-related features, including hepatic steatosis, increased left ventricular mass, and proteinuria, are strongly associated with IOP.
Authors: Y-H Kim; S W Jung; G-E Nam; K Do Han; A R Bok; S J Baek; K-H Cho; Y S Choi; S-M Kim; S-Y Ju; D-H Kim Journal: Eye (Lond) Date: 2014-03-07 Impact factor: 3.775
Authors: E F S Castro; C T Mostarda; B Rodrigues; I C Moraes-Silva; D J Feriani; K De Angelis; M C Irigoyen Journal: Braz J Med Biol Res Date: 2015-02-13 Impact factor: 2.590