OBJECTIVE: The risk of atherosclerosis in the setting of chylomicronemia has been a topic of debate. In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis. METHODS AND RESULTS: Gpihbp1(-/-) mice on a chow diet have plasma triglyceride and cholesterol levels of 2812+/-209 and 319+/-27 mg/dL, respectively. Even though nearly all of the lipids were contained in large lipoproteins (50 to 135 nm), the mice developed progressive aortic atherosclerosis. In other experiments, we found that both Gpihbp1-deficient "apo-B48-only" mice and Gpihbp1-deficient "apo-B100-only" mice manifest severe chylomicronemia. Thus, GPIHBP1 is required for the processing of both apo-B48- and apo-B100-containing lipoproteins. CONCLUSIONS: Chylomicronemia causes atherosclerosis in mice. Also, we found that GPIHBP1 is required for the lipolytic processing of both apo-B48- and apo-B100-containing lipoproteins.
OBJECTIVE: The risk of atherosclerosis in the setting of chylomicronemia has been a topic of debate. In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficientmice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis. METHODS AND RESULTS:Gpihbp1(-/-)mice on a chow diet have plasma triglyceride and cholesterol levels of 2812+/-209 and 319+/-27 mg/dL, respectively. Even though nearly all of the lipids were contained in large lipoproteins (50 to 135 nm), the mice developed progressive aortic atherosclerosis. In other experiments, we found that both Gpihbp1-deficient "apo-B48-only" mice and Gpihbp1-deficient "apo-B100-only" mice manifest severe chylomicronemia. Thus, GPIHBP1 is required for the processing of both apo-B48- and apo-B100-containing lipoproteins. CONCLUSIONS:Chylomicronemia causes atherosclerosis in mice. Also, we found that GPIHBP1 is required for the lipolytic processing of both apo-B48- and apo-B100-containing lipoproteins.
Authors: J G Strauss; S Frank; D Kratky; G Hämmerle; A Hrzenjak; G Knipping; A von Eckardstein; G M Kostner; R Zechner Journal: J Biol Chem Date: 2001-06-29 Impact factor: 5.157
Authors: Anne P Beigneux; Brandon S J Davies; Peter Gin; Michael M Weinstein; Emily Farber; Xin Qiao; Franklin Peale; Stuart Bunting; Rosemary L Walzem; Jinny S Wong; William S Blaner; Zhi-Ming Ding; Kristan Melford; Nuttaporn Wongsiriroj; Xiao Shu; Fred de Sauvage; Robert O Ryan; Loren G Fong; André Bensadoun; Stephen G Young Journal: Cell Metab Date: 2007-04 Impact factor: 27.287
Authors: Chun-Min Lo; Brian K Nordskog; Andromeda M Nauli; Shuqin Zheng; Sarah B Vonlehmden; Qing Yang; Dana Lee; Larry L Swift; Nicholas O Davidson; Patrick Tso Journal: Am J Physiol Gastrointest Liver Physiol Date: 2007-11-15 Impact factor: 4.052
Authors: Xiaohong Zhang; Rong Qi; Xunde Xian; Fei Yang; Michael Blackstein; Xuming Deng; Jianglin Fan; Colin Ross; Joanna Karasinska; Michael R Hayden; George Liu Journal: Circ Res Date: 2007-11-21 Impact factor: 17.367
Authors: Anne P Beigneux; Remco Franssen; André Bensadoun; Peter Gin; Kristan Melford; Jorge Peter; Rosemary L Walzem; Michael M Weinstein; Brandon S J Davies; Jan A Kuivenhoven; John J P Kastelein; Loren G Fong; Geesje M Dallinga-Thie; Stephen G Young Journal: Arterioscler Thromb Vasc Biol Date: 2009-03-19 Impact factor: 8.311
Authors: Luciano F Drager; Thauany M Tavoni; Vanessa M Silva; Raul D Santos; Rodrigo P Pedrosa; Luiz A Bortolotto; Carmen G Vinagre; Vsevolod Y Polotsky; Geraldo Lorenzi-Filho; Raul C Maranhao Journal: J Lipid Res Date: 2018-04-08 Impact factor: 5.922
Authors: Haibo Jiang; Chris N Goulbourne; Angelica Tatar; Kirsten Turlo; Daniel Wu; Anne P Beigneux; Chris R M Grovenor; Loren G Fong; Stephen G Young Journal: J Lipid Res Date: 2014-08-20 Impact factor: 5.922
Authors: Geesje M Dallinga-Thie; Remco Franssen; Hans L Mooij; Maartje E Visser; H Carlijne Hassing; Frank Peelman; John J P Kastelein; Miklós Péterfy; Max Nieuwdorp Journal: Atherosclerosis Date: 2009-12-29 Impact factor: 5.162
Authors: Tove Olafsen; Stephen G Young; Brandon S J Davies; Anne P Beigneux; Vania E Kenanova; Constance Voss; Glen Young; Koon-Pong Wong; Richard H Barnes; Yiping Tu; Michael M Weinstein; Chika Nobumori; Sung-Cheng Huang; Ira J Goldberg; André Bensadoun; Anna M Wu; Loren G Fong Journal: J Biol Chem Date: 2010-09-30 Impact factor: 5.157
Authors: Nathan T Jenkins; Jaume Padilla; Pamela K Thorne; Jeffrey S Martin; R Scott Rector; J Wade Davis; M Harold Laughlin Journal: J Appl Physiol (1985) Date: 2014-01-16
Authors: Lars Berglund; John D Brunzell; Anne C Goldberg; Ira J Goldberg; Frank Sacks; Mohammad Hassan Murad; Anton F H Stalenhoef Journal: J Clin Endocrinol Metab Date: 2012-09 Impact factor: 5.958
Authors: Loren G Fong; Stephen G Young; Anne P Beigneux; André Bensadoun; Monika Oberer; Haibo Jiang; Michael Ploug Journal: Trends Endocrinol Metab Date: 2016-05-14 Impact factor: 12.015