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Literature DB >> 19814668

Ischemic tolerance in stroke treatment.

Nora Sandu¹, Jan Cornelius, Andreas Filis, Belachew Arasho, Miguel Perez-Pinzon, Bernhard Schaller.

Abstract

Although outcome after stroke treatment has significantly improved over the last 30 years, there has been no revolutionary breakthrough. Among different combined approaches, systemic thrombolysis in combination with neuroprotection became a favorite research target. Recent studies suggest that transient ischemic attacks may represent a clinical model of such ischemic tolerance; thus, a new focus on this research has emerged. In this review, we show the parallels between ischemia and neuroprotection and discuss the potential therapeutic options that may be opened by this new molecular knowledge.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Neuroprotective Agents

Year: 2009 PMID： 19814668 PMCID： PMC2881628 DOI： 10.1586/erc.09.90

Source DB: PubMed Journal: Expert Rev Cardiovasc Ther ISSN： 1477-9072

45 in total

Review 1. Neuroprotection in primary brain tumors: sense or nonsense?

Authors: Bernhard J Schaller; Michael Buchfelder
Journal: Expert Rev Neurother Date: 2006-05 Impact factor: 4.618

Review 2. Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death.

Authors: Donald J DeGracia; Rita Kumar; Cheri R Owen; Gary S Krause; Blaine C White
Journal: J Cereb Blood Flow Metab Date: 2002-02 Impact factor: 6.200

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Journal: Stroke Date: 1994-03 Impact factor: 7.914

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Journal: J Mol Cell Cardiol Date: 1997-11 Impact factor: 5.000

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Authors: J Bogousslavsky; G Van Melle; F Regli
Journal: Stroke Date: 1988-09 Impact factor: 7.914

7. Transient ischemic attacks before ischemic stroke: preconditioning the human brain? A multicenter magnetic resonance imaging study.

Authors: Susanne Wegener; Barbara Gottschalk; Verica Jovanovic; René Knab; Jochen B Fiebach; Peter D Schellinger; Thomas Kucinski; Gerhard J Jungehülsing; Peter Brunecker; Bianca Müller; Anna Banasik; Nicola Amberger; Klaus D Wernecke; Mario Siebler; Joachim Röther; Arno Villringer; Markus Weih
Journal: Stroke Date: 2004-02-12 Impact factor: 7.914

Ischemic tolerance in stroke treatment.

Review 1. Neuroprotection in primary brain tumors: sense or nonsense?

Review 2. Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death.

3. Could transient ischemic attacks have a cerebroprotective role?

4. Decrease in ischemic tolerance with aging in isolated perfused Fischer 344 rat hearts: relation to increases in intracellular Na+ after ischemia.

5. Tissue plasminogen activator for acute ischemic stroke.

6. The Lausanne Stroke Registry: analysis of 1,000 consecutive patients with first stroke.

7. Transient ischemic attacks before ischemic stroke: preconditioning the human brain? A multicenter magnetic resonance imaging study.

Review 8. Molecular physiology of preconditioning-induced brain tolerance to ischemia.

9. Preconditioning does not prevent postischemic dysfunction in aging heart.

10. Oxygen-conserving reflexes of the brain: the current molecular knowledge.

Review 1. Plasticity of Sensorimotor Networks: Multiple Overlapping Mechanisms.

2. Can genes modify stroke outcome and by what mechanisms?

3. Neuron specific metabolic adaptations following multi-day exposures to oxygen glucose deprivation.

4. Refocusing the Brain: New Approaches in Neuroprotection Against Ischemic Injury.

5. The role of the immunoinflammatory response after cardiac arrest.