Literature DB >> 19814625

Immunological and biochemical correlates of adjunctive dexamethasone in Vietnamese adults with bacterial meningitis.

Nguyen Thi Hoang Mai1, Trung Vu Tuan, Marcel Wolbers, Dang Minh Hoang, Tran Vu Thieu Nga, Tran Thi Hong Chau, Ly Van Chuong, Dinh Xuan Sinh, Ho Dang Trung Nghia, Nguyen Duy Phong, Nguyen Hoan Phu, To Song Diep, Hoang Thi Thanh Hang, Nguyen van Vinh Chau, Jeremy Farrar, Constance Schultsz, Tran Tinh Hien, Cameron P Simmons.   

Abstract

Adjunctive treatment to improve outcome from bacterial meningitis has centered on dexamethasone. Among Vietnamese patients with bacterial meningitis, cerebrospinal fluid (CSF) opening pressure and CSF:plasma glucose ratios were significantly improved and levels of CSF cytokines interleukin (IL)-6, IL-8, and IL-10 and were all statistically significantly lower after treatment in patients who were randomized to dexamethasone, compared with levels in patients who received placebo.

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Year:  2009        PMID： 19814625      PMCID： PMC4340500          DOI： 10.1086/630207

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  18 in total

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4.  Dexamethasone therapy for bacterial meningitis. Results of two double-blind, placebo-controlled trials.

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6.  Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomised controlled trial.

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9.  Adjuvant glycerol and/or dexamethasone to improve the outcomes of childhood bacterial meningitis: a prospective, randomized, double-blind, placebo-controlled trial.

Authors:  Heikki Peltola; Irmeli Roine; Josefina Fernández; Inés Zavala; Silvia González Ayala; Antonio González Mata; Antonio Arbo; Rosa Bologna; Greta Miño; José Goyo; Eduardo López; Solange Dourado de Andrade; Seppo Sarna
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10.  Dexamethasone in the treatment of experimental Haemophilus influenzae type b meningitis.

Authors:  G A Syrogiannopoulos; K D Olsen; J S Reisch; G H McCracken
Journal:  J Infect Dis       Date:  1987-02       Impact factor: 5.226
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4.  LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome.

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5.  Response of Vancomycin according to Steroid Dosage in Pediatric Patients with Culture-Proven Bacterial Meningitis.

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6.  CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults With Streptococcus pneumoniae Meningitis.

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