Literature DB >> 19811534

IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse retina.

Osamu Katsumata1, Naoki Ohara, Hideaki Tamaki, Tomoko Niimura, Hideaki Naganuma, Masahiko Watanabe, Hiroyuki Sakagami.   

Abstract

IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for ADP ribosylation factors (Arfs), which are implicated in membrane trafficking and actin cytoskeleton dynamics. In this study, we examined the immunohistochemical localization of IQ-ArfGEF/BRAG1 in the adult mouse retina using light and electron microscopy. IQ-ArfGEF/BRAG1 was distributed in a punctate manner and colocalized well with RIBEYE in both the outer and inner plexiform layers. Immunoelectron microscopic analysis showed that IQ-ArfGEF/BRAG1 was localized at the synaptic ribbons of photoreceptors. When heterologously expressed in HeLa cells, IQ-ArfGEF/BRAG1 was recruited to RIBEYE-containing clusters and formed an immunoprecipitable complex with RIBEYE. Furthermore, immunoprecipitation analysis showed that anti-IQ-ArfGEF/BRAG1 antibody efficiently pulled down RIBEYE from retinal lysates. These findings indicate that IQ-ArfGEF/BRAG1 is a novel component of retinal synaptic ribbons and forms a protein complex with RIBEYE.

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Year:  2009        PMID： 19811534     DOI： 10.1111/j.1460-9568.2009.06943.x

Source DB:  PubMed          Journal:  Eur J Neurosci        ISSN： 0953-816X            Impact factor:   3.386


  8 in total

1.  Subtle functional defects in the Arf-specific guanine nucleotide exchange factor IQSEC2 cause non-syndromic X-linked intellectual disability.

Authors:  Cheryl Shoubridge; Randall S Walikonis; Jozef Gécz; Robert J Harvey
Journal:  Small GTPases       Date:  2010-09

2.  Histamine receptors of cones and horizontal cells in Old World monkey retinas.

Authors:  Alejandro Vila; Hiromasa Satoh; Carolina Rangel; Stephen L Mills; Hideo Hoshi; John O'Brien; Daniel R Marshak; Peter R Macleish; David W Marshak
Journal:  J Comp Neurol       Date:  2012-02-15       Impact factor: 3.215

3.  Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature.

Authors:  Muhammad Ansar; Hyung-Lok Chung; Ali Al-Otaibi; Mohammad Nael Elagabani; Thomas A Ravenscroft; Sohail A Paracha; Ralf Scholz; Tayseer Abdel Magid; Muhammad T Sarwar; Sayyed Fahim Shah; Azhar Ali Qaisar; Periklis Makrythanasis; Paul C Marcogliese; Erik-Jan Kamsteeg; Emilie Falconnet; Emmanuelle Ranza; Federico A Santoni; Hesham Aldhalaan; Ali Al-Asmari; Eissa Ali Faqeih; Jawad Ahmed; Hans-Christian Kornau; Hugo J Bellen; Stylianos E Antonarakis
Journal:  Am J Hum Genet       Date:  2019-10-10       Impact factor: 11.025

Review 4.  The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteins.

Authors:  Aaron J Mercer; Wallace B Thoreson
Journal:  Vis Neurosci       Date:  2011-11       Impact factor: 3.241

5.  Membrane-associated guanylate kinase scaffolds organize a horizontal cell synaptic complex restricted to invaginating contacts with photoreceptors.

Authors:  Alejandro Vila; Christopher M Whitaker; John O'Brien
Journal:  J Comp Neurol       Date:  2016-09-21       Impact factor: 3.215

6.  Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice.

Authors:  Vera L Bonilha; Brent A Bell; Mary E Rayborn; Xiaoping Yang; Charlie Kaul; Gregory H Grossman; Ivy S Samuels; Joe G Hollyfield; Chengsong Xie; Huaibin Cai; Karen G Shadrach
Journal:  Exp Eye Res       Date:  2015-07-26       Impact factor: 3.467

7.  High-resolution optical imaging of zebrafish larval ribbon synapse protein RIBEYE, RIM2, and CaV 1.4 by stimulation emission depletion microscopy.

Authors:  Caixia Lv; Travis J Gould; Joerg Bewersdorf; David Zenisek
Journal:  Microsc Microanal       Date:  2012-07-26       Impact factor: 4.127

8.  Molecular anatomy of the hair cell's ribbon synapse.

Authors:  Revathy C Uthaiah; A J Hudspeth
Journal:  J Neurosci       Date:  2010-09-15       Impact factor: 6.167
  8 in total

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