Literature DB >> 19811323

Molecular mechanisms of IFN-gamma to up-regulate MHC class I antigen processing and presentation.

Fang Zhou1.   

Abstract

IFN-gamma up-regulates MHC class I expression and antigen processing and presentation on cells, since IFN-gamma can induce multiple gene expressions that are related to MHC class I antigen processing and presentation. MHC class I antigen presentation-associated gene expression is initiated by IRF-1. IRF-1 expression is initiated by phosphorylated STAT1. IFN-gamma binds to IFN receptors, and then activates JAK1/JAK2/STAT1 signal transduction via phosphorylation of JAK and STAT1 in cells. IFN-gamma up-regulates MHC class I antigen presentation via activation of JAK/STAT1 signal transduction pathway. Mechanisms of IFN-gamma to enhance MHC class I antigen processing and presentation were summarized in this literature review.

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Year:  2009        PMID： 19811323     DOI： 10.1080/08830180902978120

Source DB:  PubMed          Journal:  Int Rev Immunol        ISSN： 0883-0185            Impact factor:   5.311


  124 in total

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Journal:  Sci Transl Med       Date:  2019-09-25       Impact factor: 17.956

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Review 3.  Census of cytosolic aminopeptidase activity reveals two novel cytosolic aminopeptidases.

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Journal:  Eur J Immunol       Date:  2014-05-23       Impact factor: 5.532

7.  Intravenous transfer of apoptotic cell-treated dendritic cells leads to immune tolerance by blocking Th17 cell activity.

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Journal:  J Clin Invest       Date:  2020-09-01       Impact factor: 14.808

9.  Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node.

Authors:  Georgia Perona-Wright; Katja Mohrs; Markus Mohrs
Journal:  Nat Immunol       Date:  2010-04-25       Impact factor: 25.606

10.  SH2 modified STAT1 induces HLA-I expression and improves IFN-γ signaling in IFN-α resistant HCV replicon cells.

Authors:  Bret Poat; Sidhartha Hazari; Partha K Chandra; Feyza Gunduz; Luis A Balart; Xavier Alvarez; Srikanta Dash
Journal:  PLoS One       Date:  2010-09-30       Impact factor: 3.240
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