Literature DB >> 1981017

A double-blind comparison of bisoprolol and captopril for treatment of essential hypertension in the elderly.

D Bracchetti1, R Gradnik, A Alberti, A Brunelli, L Orselli, G Leonardi, P C Pavesi, I Cantelli.   

Abstract

The aim of the study was to compare the antihypertensive efficacy and safety of a new beta blocker with high beta 1 selectivity, bisoprolol, with captopril in 28 elderly patients, aged over 65 years, with mild-to-moderate essential hypertension (WHO classes I and II). After a placebo run-in period of 4 weeks, the patients were randomly allocated to receive bisoprolol (5 mg od) or captopril (25 mg bid) (double-dummy technique) for 6 weeks, according to a crossover double-blind design, with a 4-week washout period between the two active treatments. The doses were doubled after 2 weeks if the supine blood pressure was greater than 160/95 mmHg. In basal conditions and after 2, 4, and 6 weeks of each treatment, the blood pressure and heart rate were assessed both in the supine and erect positions. At the same time, the side effects and quality of life were investigated by a checklist and a self-assessment questionnaire. Standard laboratory tests and a resting ECG tracing were performed before and after each active treatment. The data from 24 patients (4 dropouts) showed a significant antihypertensive effect of both treatments (p less than 0.01) with a reduction of diastolic blood pressure to values less than or equal to 95 mmHg in 75% (18/24) of the patients treated with bisoprolol and in 83.3% (20/24) of those treated with captopril, without significant differences between the two drugs. Bisoprolol also produces a marked but symptom-free reduction of heart rate compared with captopril (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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Year:  1990        PMID: 1981017     DOI: 10.1007/bf01857642

Source DB:  PubMed          Journal:  Cardiovasc Drugs Ther        ISSN: 0920-3206            Impact factor:   3.727


  17 in total

1.  Arterial hypertension. Report of a WHO expert committee.

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Journal:  World Health Organ Tech Rep Ser       Date:  1978

2.  The 1988 report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure.

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Journal:  Arch Intern Med       Date:  1988-05

3.  Long-term effects of bisoprolol on blood pressure, serum lipids, and HDL-cholesterol in patients with essential hypertension.

Authors:  G Frithz; L Weiner
Journal:  J Cardiovasc Pharmacol       Date:  1986       Impact factor: 3.105

4.  Beta-blockers and asthma.

Authors:  P B Decalmer; S S Chatterjee; J M Cruickshank; M K Benson; G M Sterling
Journal:  Br Heart J       Date:  1978-02

5.  Cardiovascular risk and risk factors in a randomized trial of treatment based on the beta-blocker oxprenolol: the International Prospective Primary Prevention Study in Hypertension (IPPPSH). The IPPPSH Collaborative Group.

Authors: 
Journal:  J Hypertens       Date:  1985-08       Impact factor: 4.844

6.  Antihypertensive effects of bisoprolol during once daily administration in patients with essential hypertension. A dose-ranging study with parallel groups.

Authors:  L Weiner; G Frithz
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

7.  Effects of long-term, once-daily administration of atenolol on ambulatory blood pressure of hypertensive patients.

Authors:  J S Floras; J V Jones; P Fox; M O Hassan; K L Turner; P Sleight
Journal:  J Cardiovasc Pharmacol       Date:  1981 Sep-Oct       Impact factor: 3.105

8.  Influence of antihypertensive drug treatment on morbidity and mortality in patients over the age of 60 years. European Working Party on High blood pressure in the Elderly (EWPHE) results: sub-group analysis on entry stratification.

Authors:  A Amery; W Birkenhäger; P Brixko; C Bulpitt; D Clement; P de Leeuw; J F de Plaen; M Deruyttere; A De Schaepdryver; C Dollery
Journal:  J Hypertens Suppl       Date:  1986-12

9.  Long-term antihypertensive therapy with captopril.

Authors:  J T Groel; S S Tadros; G R Dreslinski; A C Jenkins
Journal:  Hypertension       Date:  1983 Sep-Oct       Impact factor: 10.190

10.  Atenolol and metoprolol once daily in hypertension.

Authors:  A K Scott; J W Rigby; J Webster; G M Hawksworth; J C Petrie; H G Lovell
Journal:  Br Med J (Clin Res Ed)       Date:  1982-05-22
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  1 in total

Review 1.  Therapeutic Properties of Highly Selective β-blockers With or Without Additional Vasodilator Properties: Focus on Bisoprolol and Nebivolol in Patients With Cardiovascular Disease.

Authors:  Waleed AlHabeeb; Sanaa Mrabeti; Ahmed Adel Ibrahim Abdelsalam
Journal:  Cardiovasc Drugs Ther       Date:  2021-06-09       Impact factor: 3.947

  1 in total

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