Challenges for the basis of practice in heart failure.

Although evidence from clinical trials has significantly informed the management of patients with heart failure, many patients and many clinical situations encountered on a daily basis do not fit neatly into the narrow definitions of trials. In subsequent issues, Circulation: Heart Failure will feature a new series entitled "Challenges for the Basis of Practice," in which readers may submit challenging cases that call for management considerations and decisions that extend well beyond the evidence. An expert consultant will be invited to comment, and readers can also submit responses to these challenging situations so that numerous viewpoints can be explored.