| Literature DB >> 19808014 |
Brent E Wisse1, Michael W Schwartz.
Abstract
Obesity-induced inflammation causes cellular resistance to both insulin and leptin. In this issue, Brüning and colleagues (Kleinridders et al., 2009) add to growing evidence that this response occurs in the hypothalamus, as well as in peripheral tissues, which helps to explain how high-fat feeding induces a gradual increase in defended body weight.Entities:
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Year: 2009 PMID: 19808014 DOI: 10.1016/j.cmet.2009.09.003
Source DB: PubMed Journal: Cell Metab ISSN: 1550-4131 Impact factor: 27.287