Literature DB >> 19805415

Rapamycin: the cure for all that ails.

Paul Hasty1.   

Abstract

Target of rapamycin (TOR) signaling stimulates cell growth by regulating protein synthesis in response to a variety of stimuli in a wide range of species and is inhibited by rapamycin, a naturally occurring antifungal compound produced by bacteria and discovered on Easter Island or in the local vernacular, Rapa Nui (rapamycin's namesake). Recently, rapamycin was shown to extend life span for mice, even when administered late in life, suggesting that inhibiting the mammalian TOR pathway may improve health span for people.

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Year:  2009        PMID: 19805415     DOI: 10.1093/jmcb/mjp033

Source DB:  PubMed          Journal:  J Mol Cell Biol        ISSN: 1759-4685            Impact factor:   6.216


  9 in total

1.  Listening to public concerns about human life extension. The public view of life-extension technologies is more nuanced than expected and researchers must engage in discussions if they hope to promote awareness and acceptance.

Authors:  Brad Partridge; Jayne Lucke; Wayne Hall
Journal:  EMBO Rep       Date:  2010-09-10       Impact factor: 8.807

Review 2.  Aging and TOR: interwoven in the fabric of life.

Authors:  Zelton Dave Sharp
Journal:  Cell Mol Life Sci       Date:  2010-10-21       Impact factor: 9.261

3.  Rapamycin promotes beta-amyloid production via ADAM-10 inhibition.

Authors:  Sheqing Zhang; Jon Salemi; Hauyan Hou; Yuyan Zhu; Takashi Mori; Brian Giunta; Demian Obregon; Jun Tan
Journal:  Biochem Biophys Res Commun       Date:  2010-06-11       Impact factor: 3.575

4.  eRapa restores a normal life span in a FAP mouse model.

Authors:  Paul Hasty; Carolina B Livi; Sherry G Dodds; Diane Jones; Randy Strong; Martin Javors; Kathleen E Fischer; Lauren Sloane; Kruthi Murthy; Gene Hubbard; Lishi Sun; Vincent Hurez; Tyler J Curiel; Zelton Dave Sharp
Journal:  Cancer Prev Res (Phila)       Date:  2013-11-26

5.  mTORC1 and p53: clash of the gods?

Authors:  Paul Hasty; Zelton Dave Sharp; Tyler J Curiel; Judith Campisi
Journal:  Cell Cycle       Date:  2013-01-01       Impact factor: 4.534

6.  Tissue-specific responses of IGF-1/insulin and mTOR signaling in calorie restricted rats.

Authors:  Naveen Sharma; Carlos M Castorena; Gregory D Cartee
Journal:  PLoS One       Date:  2012-06-06       Impact factor: 3.240

7.  p53 and rapamycin are additive.

Authors:  Barbara Christy; Marco Demaria; Judith Campisi; Jing Huang; Diane Jones; Sherry G Dodds; Charnae Williams; Gene Hubbard; Carolina B Livi; Xiaoli Gao; Susan Weintraub; Tyler Curiel; Z Dave Sharp; Paul Hasty
Journal:  Oncotarget       Date:  2015-06-30

8.  Effects of inhibiting mTOR with rapamycin on behavior, development, neuromuscular physiology and cardiac function in larval Drosophila.

Authors:  Samuel Potter; Jacob Sifers; Emily Yocom; Sandra L E Blümich; Rachel Potter; Jeremy Nadolski; Douglas A Harrison; Robin L Cooper
Journal:  Biol Open       Date:  2019-11-21       Impact factor: 2.422

9.  LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis.

Authors:  Xuedan Sun; Rick Francis Thorne; Xu Dong Zhang; Miao He; Jinming Li; Shanshan Feng; Xiaoying Liu; Mian Wu
Journal:  EMBO Rep       Date:  2020-03-09       Impact factor: 8.807

  9 in total

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