| Literature DB >> 19804971 |
Jiwen Liu1, Zice Fu, Yingcai Wang, Mike Schmitt, Alan Huang, Derek Marshall, George Tonn, Lisa Seitz, Tim Sullivan, H Lucy Tang, Tassie Collins, Julio Medina.
Abstract
A series of phenylacetic acid derivatives was discovered as CRTH2 antagonists. Modification of the series led to compounds that are also antagonists of DP. Since activation of CRTH2 and DP are believed to play key roles in mediating responses of asthma and other immune diseases, this series was optimized to increase the dual antagonistic activities and improve pharmacokinetic properties. These efforts led to selection of AMG 009 as a clinical candidate.Entities:
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Year: 2009 PMID： 19804971 DOI： 10.1016/j.bmcl.2009.09.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823