Literature DB >> 19804904

Clonal hematopoiesis in Philadelphia chromosome-negative bone marrow cells of chronic myeloid leukemia patients receiving dasatinib.

Ronald L Paquette1, John Nicoll, Meenal Chalukya, Lucas Gondek, Monika Jasek, Charles L Sawyers, Neil P Shah, Jaroslaw Maciejewski.   

Abstract

A clonal cytogenetic abnormality was observed in Philadelphia chromosome-negative bone marrow cells of 6/27 chronic myeloid leukemia patients (+8 in 4, -7 in 1, and 20q- in 1) with dasatinib-induced remissions. The X-linked human androgen receptor gene assay demonstrated clonality in one additional patient. Single nucleotide polymorphism array analysis revealed somatic uniparental disomy involving chromosome 17(p12-pter) in another patient. The TP53 gene had a 5' splice site deletion of exon 6 that caused alternative splicing, frame shifting and introduction of a premature stop codon. After three years, no patient developed myelodysplastic syndrome or acute myeloid leukemia. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19804904      PMCID： PMC5821258          DOI： 10.1016/j.leukres.2009.08.032

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  31 in total

1.  Chromosomal abnormalities in Ph- cells of patients on imatinib.

Authors:  Mary F McMullin; Mervyn Humphreys; Jenny Byrne; Nigel H Russell; Robert J Cuthbert; Michael E O'Dwyer
Journal:  Blood       Date:  2003-10-01       Impact factor: 22.113

2.  Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority.

Authors:  Thomas Bumm; Christel Müller; Haifa-Kathrin Al-Ali; Knut Krohn; Patricia Shepherd; Erika Schmidt; Sabine Leiblein; Christina Franke; Evelin Hennig; Thomas Friedrich; Reiner Krahl; Dietger Niederwieser; Michael W N Deininger
Journal:  Blood       Date:  2002-10-31       Impact factor: 22.113

3.  Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: report of three cases.

Authors:  L Fayad; H Kantarjian; S O'Brien; D Seong; M Albitar; M Keating; M Talpaz
Journal:  Leukemia       Date:  1997-05       Impact factor: 11.528

4.  Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias.

Authors:  Moshe Talpaz; Neil P Shah; Hagop Kantarjian; Nicholas Donato; John Nicoll; Ron Paquette; Jorge Cortes; Susan O'Brien; Claude Nicaise; Eric Bleickardt; M Anne Blackwood-Chirchir; Vishwanath Iyer; Tai-Tsang Chen; Fei Huang; Arthur P Decillis; Charles L Sawyers
Journal:  N Engl J Med       Date:  2006-06-15       Impact factor: 91.245

5.  Clonal X-inactivation analysis of human tumours using the human androgen receptor gene (HUMARA) polymorphism: a non-radioactive and semiquantitative strategy applicable to fresh and archival tissue.

Authors:  P Kopp; R Jaggi; A Tobler; B Borisch; M Oestreicher; L Sabacan; J L Jameson; M F Fey
Journal:  Mol Cell Probes       Date:  1997-06       Impact factor: 2.365

6.  Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate.

Authors:  M E O'Dwyer; K M Gatter; M Loriaux; B J Druker; S B Olson; R E Magenis; H Lawce; M J Mauro; R T Maziarz; R M Braziel
Journal:  Leukemia       Date:  2003-03       Impact factor: 11.528

7.  Dynamics of cytogenetic aberrations in Philadelphia chromosome positive and negative hematopoiesis during dasatinib therapy of chronic myeloid leukemia patients after imatinib failure.

Authors:  Alice Fabarius; Claudia Haferlach; Martin C Müller; Philipp Erben; Tanja Lahaye; Michelle Giehl; Oliver Frank; Wolfgang Seifarth; Rüdiger Hehlmann; Andreas Hochhaus
Journal:  Haematologica       Date:  2007-06       Impact factor: 9.941

8.  Identification of a novel, transactivation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia.

Authors:  Sona Pekova; Radek Cmejla; Lukas Smolej; Tomas Kozak; Martin Spacek; Miroslav Prucha
Journal:  Leuk Res       Date:  2007-08-03       Impact factor: 3.156

9.  Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes.

Authors:  Azim Mohamedali; Joop Gäken; Natalie A Twine; Wendy Ingram; Nigel Westwood; Nicholas C Lea; Janet Hayden; Nora Donaldson; Carlo Aul; Norbert Gattermann; Aristotle Giagounidis; Ulrich Germing; Alan F List; Ghulam J Mufti
Journal:  Blood       Date:  2007-07-18       Impact factor: 22.113

10.  Langerhans'-cell histiocytosis (histiocytosis X)--a clonal proliferative disease.

Authors:  C L Willman; L Busque; B B Griffith; B E Favara; K L McClain; M H Duncan; D G Gilliland
Journal:  N Engl J Med       Date:  1994-07-21       Impact factor: 91.245
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  1 in total

1.  Poor prognosis of chromosome 7 clonal aberrations in Philadelphia-negative metaphases and relevance of potential underlying myelodysplastic features in chronic myeloid leukemia.

Authors:  Audrey Bidet; Stéphanie Dulucq; Thomas Smol; Alice Marceau-Renaut; Stéphane Morisset; Valérie Coiteux; Marie-Pierre Noël-Walter; Franck-Emmanuel Nicolini; Isabelle Tigaud; Isabelle Luquet; Stéphanie Struski; Baptiste Gaillard; Dominique Penther; Sylvie Tondeur; Nathalie Nadal; Eric Hermet; Lauren Véronèse; Delphine Réa; Carine Gervais; Olivier Theisen; Christine Terré; Pascale Cony-Makhoul; Christine Lefebvre; Jean-Baptiste Gaillard; Isabelle Radford; Anne-Laure Vervaeke; Carole Barin; Elise Chapiro; Florence Nguyen-Khac; Gabriel Etienne; Claude Preudhomme; François Xavier Mahon; Catherine Roche-Lestienne
Journal:  Haematologica       Date:  2018-12-20       Impact factor: 9.941
  1 in total

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