Literature DB >> 198047

Stimulation of the hexose monophosphate shunt independent of hydrogen peroxide and superoxide production in rabbit alveolar macrophages during phagocytosis.

M F Tsan.   

Abstract

Phagocytosis and oxidative metabolism of human polymorphonuclear leukocytes (PMN) and rabbit alveolar macrophages (AM) were studied. Human PMN ingested a mean of 12 polyvinyl toluene latex particles (2 micrometer in diameter) per cell. There was stimulation of O2- and H2O2 production, light emission, and activation of the hexose monophosphate shunt during phagocytosis by human PMN. Rabbit AM ingested 51 latex particles (2 micrometer in diameter) per cell. There was no stimulation of the production of O2- and H2O2 or light emission associated with phagocytosis by rabbit AM, while the hexose monophosphate shunt was activated. Similar metabolic changes were obtained in both cell types when opsonized zymosan was used as phagocytic particles. 1-14C-glucoseoxidation was stimulated by H2O2 and methylene blue in both resting human PMN and rabbit AM. It is concluded that activation of the hexose monophosphate shunt in rabbit AM during phagocytosis is independent of O2- and H2O2 production.

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Year:  1977        PMID： 198047

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  9 in total

1.  Decreased phagocytosis and superoxide anion production in alveolar macrophages of rats exposed to nitrogen dioxide.

Authors:  T Suzuki; S Ikeda; T Kanoh; I Mizoguchi
Journal:  Arch Environ Contam Toxicol       Date:  1986-11       Impact factor: 2.804

2.  A continuous alveolar macrophage cell line: comparisons with freshly derived alveolar macrophages.

Authors:  R J Helmke; V F German; J A Mangos
Journal:  In Vitro Cell Dev Biol       Date:  1989-01

3.  Chemiluminescence response of equine alveolar macrophages during stimulation with latex beads, or IgG-opsonized sheep red blood cells.

Authors:  R M Dyer; R W Leid
Journal:  Inflammation       Date:  1983-06       Impact factor: 4.092

4.  Hexokinase II binding to mitochondria is necessary for Kupffer cell activation and is potentiated by ethanol exposure.

Authors:  Nataly Shulga; John G Pastorino
Journal:  J Biol Chem       Date:  2014-08-05       Impact factor: 5.157

5.  In vitro generation of hydrogen peroxide and of superoxide anion by bovine polymorphonuclear neutrophilic granulocytes, blood monocytes, and alveolar macrophages.

Authors:  H Bielefeldt Ohmann; L A Babiuk
Journal:  Inflammation       Date:  1984-09       Impact factor: 4.092

6.  Production of hydroxyl radical by human alveolar macrophages.

Authors:  J R Hoidal; G D Beall; J E Repine
Journal:  Infect Immun       Date:  1979-12       Impact factor: 3.441

7.  Serum factor requirement for reactive oxygen intermediate release by rabbit alveolar macrophages.

Authors:  G F Gerberick; J B Willoughby; W F Willoughby
Journal:  J Exp Med       Date:  1985-02-01       Impact factor: 14.307

8.  Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of Trypanosoma cruzi.

Authors:  C Nathan; N Nogueira; C Juangbhanich; J Ellis; Z Cohn
Journal:  J Exp Med       Date:  1979-05-01       Impact factor: 14.307

9.  Failure to trigger the oxidative metabolic burst by normal macrophages: possible mechanism for survival of intracellular pathogens.

Authors:  C B Wilson; V Tsai; J S Remington
Journal:  J Exp Med       Date:  1980-02-01       Impact factor: 14.307
  9 in total

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