AIMS: To analyze the dose-response relationship between average daily alcohol consumption and the risk of hypertension via systematic review and meta-analysis. DESIGN: A computer-assisted search was completed for 10 databases, followed by hand searches of relevant articles. Only studies with longitudinal design, quantitative measurement of alcohol consumption and biological measurement of outcome were included. Dose-response relationships were assessed by determining the best-fitting model via first- and second-degree fractional polynomials. Various tests for heterogeneity and publication bias were conducted. FINDINGS: A total of 12 cohort studies were identified from the literature from the United States, Japan and Korea. A linear dose-response relationship with a relative risk of 1.57 at 50 g pure alcohol per day and 2.47 at 100 g per day was seen for men. Among women, the meta-analysis indicated a more modest protective effect than reported previously: a significant protective effect was reported for consumption at or below about 5 g per day, after which a linear dose-response relationship was found with a relative risk of 1.81 at 50 g per day and of 2.81 at an average daily consumption of 100 g pure alcohol per day. Among men, Asian populations had higher risks than non-Asian populations. CONCLUSIONS: The risk for hypertension increases linearly with alcohol consumption, so limiting alcohol intake should be advised for both men and women.
AIMS: To analyze the dose-response relationship between average daily alcohol consumption and the risk of hypertension via systematic review and meta-analysis. DESIGN: A computer-assisted search was completed for 10 databases, followed by hand searches of relevant articles. Only studies with longitudinal design, quantitative measurement of alcohol consumption and biological measurement of outcome were included. Dose-response relationships were assessed by determining the best-fitting model via first- and second-degree fractional polynomials. Various tests for heterogeneity and publication bias were conducted. FINDINGS: A total of 12 cohort studies were identified from the literature from the United States, Japan and Korea. A linear dose-response relationship with a relative risk of 1.57 at 50 g pure alcohol per day and 2.47 at 100 g per day was seen for men. Among women, the meta-analysis indicated a more modest protective effect than reported previously: a significant protective effect was reported for consumption at or below about 5 g per day, after which a linear dose-response relationship was found with a relative risk of 1.81 at 50 g per day and of 2.81 at an average daily consumption of 100 g pure alcohol per day. Among men, Asian populations had higher risks than non-Asian populations. CONCLUSIONS: The risk for hypertension increases linearly with alcohol consumption, so limiting alcohol intake should be advised for both men and women.
Authors: Francisco Javier Félix-Redondo; Daniel Fernández-Bergés; Luis Palomo Cobos; Francisco Buitrago Ramírez; José Fernando Pérez Castán; Luis Lozano Mera Journal: Aten Primaria Date: 2011-09-19 Impact factor: 1.137
Authors: Jürgen Rehm; Dolly Baliunas; Guilherme L G Borges; Kathryn Graham; Hyacinth Irving; Tara Kehoe; Charles D Parry; Jayadeep Patra; Svetlana Popova; Vladimir Poznyak; Michael Roerecke; Robin Room; Andriy V Samokhvalov; Benjamin Taylor Journal: Addiction Date: 2010-03-15 Impact factor: 6.526
Authors: Jayadeep Patra; Benjamin Taylor; Hyacinth Irving; Michael Roerecke; Dolly Baliunas; Satya Mohapatra; Jürgen Rehm Journal: BMC Public Health Date: 2010-05-18 Impact factor: 3.295