Literature DB >> 19804368

Cancer stem cells and the biology of brain tumors.

Debora Gazzana Flores1, Pitia Flores Ledur, Ana Lucia Abujamra, Algemir Lunardi Brunetto, Gilberto Schwartsmann, Guido Lenz, Rafael Roesler.   

Abstract

There is now compelling evidence that brain tumors harbor a small population of cells characterized by their ability to undergo self-renewal and initiate tumors, termed cancer stem cells (CSCs). The development of therapeutic strategies targeted towards CSC signaling may improve the treatment of brain tumors such as malignant gliomas and medulloblastomas. Here we review the role of cancer stem cells in glioma and medulloblastoma and some of the signaling mechanisms involved in brain tumor stem cell (BTSC) biology, and discuss how these signaling pathways may represent new stem cell targets for the treatment of brain tumors. In addition, we provide illustrative immunohistochemical data on the presence of BTSCs in human gliomas and medulloblastomas, and show preliminary findings suggesting the involvement of a GPCR, the gastrin-releasing peptide receptor (GRPR), in the expansion of BTSCs in vitro.

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Year:  2009        PMID： 19804368     DOI： 10.2174/157488809789649214

Source DB:  PubMed          Journal:  Curr Stem Cell Res Ther        ISSN： 1574-888X            Impact factor:   3.828


  9 in total

1.  Extracellular ATP reduces tumor sphere growth and cancer stem cell population in glioblastoma cells.

Authors:  Pítia Flores Ledur; Emilly Schlee Villodre; Romela Paulus; Lavinia Almeida Cruz; Débora Gazzana Flores; Guido Lenz
Journal:  Purinergic Signal       Date:  2011-08-05       Impact factor: 3.765

2.  Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells.

Authors:  Pâmela Rossi Menegotto; Patrícia Luciana da Costa Lopez; Bárbara Kunzler Souza; Caroline Brunetto de Farias; Eduardo Cremonese Filippi-Chiela; Igor Araújo Vieira; Gilberto Schwartsmann; Guido Lenz; Rafael Roesler
Journal:  Mol Neurobiol       Date:  2016-01-16       Impact factor: 5.590

3.  Laminin-adherent versus suspension-non-adherent cell culture conditions for the isolation of cancer stem cells in the DAOY medulloblastoma cell line.

Authors:  Javier de la Rosa; Ander Sáenz Antoñanzas; Mehdi H Shahi; Bárbara Meléndez; Juan A Rey; Javier S Castresana
Journal:  Tumour Biol       Date:  2016-06-15

4.  Inhibitory activities of trichostatin a in U87 glioblastoma cells and tumorsphere-derived cells.

Authors:  Felipe de Almeida Sassi; Lílian Caesar; Mariane Jaeger; Carolina Nör; Ana Lucia Abujamra; Gilberto Schwartsmann; Caroline Brunetto de Farias; Algemir Lunardi Brunetto; Patrícia Luciana da Costa Lopez; Rafael Roesler
Journal:  J Mol Neurosci       Date:  2014-01-25       Impact factor: 3.444

5.  The histone deacetylase inhibitor sodium butyrate promotes cell death and differentiation and reduces neurosphere formation in human medulloblastoma cells.

Authors:  Carolina Nör; Felipe A Sassi; Caroline Brunetto de Farias; Gilberto Schwartsmann; Ana Lucia Abujamra; Guido Lenz; Algemir Lunardi Brunetto; Rafael Roesler
Journal:  Mol Neurobiol       Date:  2013-03-21       Impact factor: 5.590

6.  Distribution of cancer stem cells in two human brain gliomas.

Authors:  Lilei Peng; Jie Fu; Weijun Wang; Florence M Hofman; Thomas C Chen; Ligang Chen
Journal:  Oncol Lett       Date:  2018-12-12       Impact factor: 2.967

Review 7.  Bombesin Receptor Family Activation and CNS/Neural Tumors: Review of Evidence Supporting Possible Role for Novel Targeted Therapy.

Authors:  Terry W Moody; Lingaku Lee; Irene Ramos-Alvarez; Tatiana Iordanskaia; Samuel A Mantey; Robert T Jensen
Journal:  Front Endocrinol (Lausanne)       Date:  2021-09-01       Impact factor: 5.555

8.  MiR-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cells.

Authors:  Ping Li; Xiaoming Lu; Yingyi Wang; Lihua Sun; Chunfa Qian; Wei Yan; Ning Liu; Yongping You; Zhen Fu
Journal:  J Biomed Res       Date:  2010-11

9.  Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR).

Authors:  Sumedh S Shah; Gregor A Rodriguez; Alexis Musick; Winston M Walters; Nicolas de Cordoba; Eric Barbarite; Megan M Marlow; Brian Marples; Jeffrey S Prince; Ricardo J Komotar; Steven Vanni; Regina M Graham
Journal:  Cancers (Basel)       Date:  2019-01-31       Impact factor: 6.639
  9 in total

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