Literature DB >> 19803785

Metabolic acetate therapy for the treatment of traumatic brain injury.

Peethambaran Arun1, Prasanth S Ariyannur, John R Moffett, Guoqiang Xing, Kristen Hamilton, Neil E Grunberg, John A Ives, Aryan M A Namboodiri.   

Abstract

Patients suffering from traumatic brain injury (TBI) have decreased markers of energy metabolism, including N-acetylaspartate (NAA) and ATP. In the nervous system, NAA-derived acetate provides acetyl-CoA required for myelin lipid synthesis. Acetate can also be oxidized in mitochondria for the derivation of metabolic energy. In the current study, using the controlled cortical impact model of TBI in rats, we investigated the effects of the hydrophobic acetate precursor, glyceryltriacetate (GTA), as a method of delivering metabolizable acetate to the injured brain. We found that GTA administration significantly increased the levels of both NAA and ATP in the injured hemisphere 4 and 6 days after injury, and also resulted in significantly improved motor performance in rats 3 days after injury.

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Year:  2010        PMID： 19803785      PMCID： PMC2824219          DOI： 10.1089/neu.2009.0994

Source DB:  PubMed          Journal:  J Neurotrauma        ISSN： 0897-7151            Impact factor:   5.269


  29 in total

Review 1.  The metabolic response to acute traumatic brain injury and implications for nutritional support.

Authors:  J L Pepe; C A Barba
Journal:  J Head Trauma Rehabil       Date:  1999-10       Impact factor: 2.710

2.  Molecular biology of acetyl-CoA metabolism.

Authors:  B J Nikolau; D J Oliver; P S Schnable; E S Wurtele
Journal:  Biochem Soc Trans       Date:  2000-12       Impact factor: 5.407

3.  Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate.

Authors:  T Fujino; J Kondo; M Ishikawa; K Morikawa; T T Yamamoto
Journal:  J Biol Chem       Date:  2001-01-09       Impact factor: 5.157

4.  Lactate administration attenuates cognitive deficits following traumatic brain injury.

Authors:  Ann C Rice; Robert Zsoldos; Tao Chen; Margaret S Wilson; B Alessandri; Robert J Hamm; M Ross Bullock
Journal:  Brain Res       Date:  2002-02-22       Impact factor: 3.252

5.  N-Acetylaspartate reduction as a measure of injury severity and mitochondrial dysfunction following diffuse traumatic brain injury.

Authors:  S Signoretti; A Marmarou; B Tavazzi; G Lazzarino; A Beaumont; R Vagnozzi
Journal:  J Neurotrauma       Date:  2001-10       Impact factor: 5.269

6.  Traumatic brain injury in the United States: A public health perspective.

Authors:  D J Thurman; C Alverson; K A Dunn; J Guerrero; J E Sniezek
Journal:  J Head Trauma Rehabil       Date:  1999-12       Impact factor: 2.710

7.  Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.

Authors:  A Luong; V C Hannah; M S Brown; J L Goldstein
Journal:  J Biol Chem       Date:  2000-08-25       Impact factor: 5.157

8.  The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat.

Authors:  K Sofia Appelberg; David A Hovda; Mayumi L Prins
Journal:  J Neurotrauma       Date:  2009-04       Impact factor: 5.269

9.  Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult rats.

Authors:  M L Prins; S M Lee; L S Fujima; D A Hovda
Journal:  J Neurochem       Date:  2004-08       Impact factor: 5.372

10.  Triacetin: a potential parenteral nutrient.

Authors:  J W Bailey; M W Haymond; J M Miles
Journal:  JPEN J Parenter Enteral Nutr       Date:  1991 Jan-Feb       Impact factor: 4.016
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  25 in total

1.  Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain.

Authors:  Prasanth S Ariyannur; John R Moffett; Chikkathur N Madhavarao; Peethambaran Arun; Nisha Vishnu; David M Jacobowitz; William C Hallows; John M Denu; Aryan M A Namboodiri
Journal:  J Comp Neurol       Date:  2010-08-01       Impact factor: 3.215

2.  Acetate supplementation attenuates lipopolysaccharide-induced neuroinflammation.

Authors:  Chris J Reisenauer; Dhaval P Bhatt; Dane J Mitteness; Evan R Slanczka; Heidi M Gienger; John A Watt; Thad A Rosenberger
Journal:  J Neurochem       Date:  2011-02-24       Impact factor: 5.372

Review 3.  A review of neuroprotection pharmacology and therapies in patients with acute traumatic brain injury.

Authors:  Kevin W McConeghy; Jimmi Hatton; Lindsey Hughes; Aaron M Cook
Journal:  CNS Drugs       Date:  2012-07-01       Impact factor: 5.749

4.  Acetate treatment increases fatty acid content in LPS-stimulated BV2 microglia.

Authors:  Dhaval P Bhatt; Thad A Rosenberger
Journal:  Lipids       Date:  2014-05-23       Impact factor: 1.880

5.  Modulation of inflammatory cytokines and mitogen-activated protein kinases by acetate in primary astrocytes.

Authors:  Mahmoud L Soliman; Colin K Combs; Thad A Rosenberger
Journal:  J Neuroimmune Pharmacol       Date:  2012-12-12       Impact factor: 4.147

6.  Potentially neuroprotective gene modulation in an in vitro model of mild traumatic brain injury.

Authors:  Valentina Di Pietro; Angela M Amorini; Barbara Tavazzi; David A Hovda; Stefano Signoretti; Christopher C Giza; Giacomo Lazzarino; Roberto Vagnozzi; Giuseppe Lazzarino; Antonio Belli
Journal:  Mol Cell Biochem       Date:  2012-12-15       Impact factor: 3.396

7.  Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression.

Authors:  Mahmoud L Soliman; Thad A Rosenberger
Journal:  Mol Cell Biochem       Date:  2011-02-26       Impact factor: 3.396

8.  Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis.

Authors:  Dhaval P Bhatt; Heidi M Houdek; John A Watt; Thad A Rosenberger
Journal:  Neurochem Int       Date:  2013-01-12       Impact factor: 3.921

9.  Acetate reduces PGE2 release and modulates phospholipase and cyclooxygenase levels in neuroglia stimulated with lipopolysaccharide.

Authors:  Mahmoud L Soliman; Joyce E Ohm; Thad A Rosenberger
Journal:  Lipids       Date:  2013-05-25       Impact factor: 1.880

Review 10.  Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies.

Authors:  Gang Cheng; Rong-hua Kong; Lei-ming Zhang; Jian-ning Zhang
Journal:  Br J Pharmacol       Date:  2012-10       Impact factor: 8.739
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