Literature DB >> 19803768

Genetic factors underlie stability of obsessive-compulsive symptoms.

Daniël S van Grootheest1, Daniëlle Cath, Jouke Jan Hottenga, Aartjan T Beekman, Dorret I Boomsma.   

Abstract

The contribution of genetic and environmental factors to the stability of obsessive-compulsive (OC) symptoms has not yet been established in adult population based samples. We obtained the Young Adult Self Report Obsessive-Compulsive Subscale in mono- and dizygotic twins from the population-based Netherlands Twin Register in 1991, 1995 and 1997 and the Padua Inventory Revised Abbreviated in 2002. Stability of OC symptoms was analyzed as a function of genetic and environmental components. Heritability of OC behavior was around 40% at each time-point, independent of the instrument used. OC behavior was moderately stable with correlations ranging between r = .2 (for 11-year intervals), .4 (for 4-5 year intervals) and .6 (for 2 year intervals). Genetic correlations across time were higher, varying between .4 and .9, indicating that the stability of OC symptoms is mainly due to stable genetic factors. This study showed a moderate heritability and stability for OC behavior in adults. Genetic stability across time is high.

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Year:  2009        PMID： 19803768     DOI： 10.1375/twin.12.5.411

Source DB:  PubMed          Journal:  Twin Res Hum Genet        ISSN： 1832-4274            Impact factor:   1.587


  7 in total

Review 1.  An integrated molecular landscape implicates the regulation of dendritic spine formation through insulin-related signalling in obsessive-compulsive disorder.

Authors:  Ilse van de Vondervoort; Geert Poelmans; Armaz Aschrafi; David L Pauls; Jan K Buitelaar; Jeffrey C Glennon; Barbara Franke
Journal:  J Psychiatry Neurosci       Date:  2016-06       Impact factor: 6.186

2.  Aetiological influences on stability and change in emotional and behavioural problems across development: a systematic review.

Authors:  L J Hannigan; N Walaker; M A Waszczuk; T A McAdams; T C Eley
Journal:  Psychopathol Rev       Date:  2016-05-21

3.  Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.

Authors:  Lea K Davis; Dongmei Yu; Clare L Keenan; Eric R Gamazon; Anuar I Konkashbaev; Eske M Derks; Benjamin M Neale; Jian Yang; S Hong Lee; Patrick Evans; Cathy L Barr; Laura Bellodi; Fortu Benarroch; Gabriel Bedoya Berrio; Oscar J Bienvenu; Michael H Bloch; Rianne M Blom; Ruth D Bruun; Cathy L Budman; Beatriz Camarena; Desmond Campbell; Carolina Cappi; Julio C Cardona Silgado; Danielle C Cath; Maria C Cavallini; Denise A Chavira; Sylvain Chouinard; David V Conti; Edwin H Cook; Vladimir Coric; Bernadette A Cullen; Dieter Deforce; Richard Delorme; Yves Dion; Christopher K Edlund; Karin Egberts; Peter Falkai; Thomas V Fernandez; Patience J Gallagher; Helena Garrido; Daniel Geller; Simon L Girard; Hans J Grabe; Marco A Grados; Benjamin D Greenberg; Varda Gross-Tsur; Stephen Haddad; Gary A Heiman; Sian M J Hemmings; Ana G Hounie; Cornelia Illmann; Joseph Jankovic; Michael A Jenike; James L Kennedy; Robert A King; Barbara Kremeyer; Roger Kurlan; Nuria Lanzagorta; Marion Leboyer; James F Leckman; Leonhard Lennertz; Chunyu Liu; Christine Lochner; Thomas L Lowe; Fabio Macciardi; James T McCracken; Lauren M McGrath; Sandra C Mesa Restrepo; Rainald Moessner; Jubel Morgan; Heike Muller; Dennis L Murphy; Allan L Naarden; William Cornejo Ochoa; Roel A Ophoff; Lisa Osiecki; Andrew J Pakstis; Michele T Pato; Carlos N Pato; John Piacentini; Christopher Pittenger; Yehuda Pollak; Scott L Rauch; Tobias J Renner; Victor I Reus; Margaret A Richter; Mark A Riddle; Mary M Robertson; Roxana Romero; Maria C Rosàrio; David Rosenberg; Guy A Rouleau; Stephan Ruhrmann; Andres Ruiz-Linares; Aline S Sampaio; Jack Samuels; Paul Sandor; Brooke Sheppard; Harvey S Singer; Jan H Smit; Dan J Stein; E Strengman; Jay A Tischfield; Ana V Valencia Duarte; Homero Vallada; Filip Van Nieuwerburgh; Jeremy Veenstra-Vanderweele; Susanne Walitza; Ying Wang; Jens R Wendland; Herman G M Westenberg; Yin Yao Shugart; Euripedes C Miguel; William McMahon; Michael Wagner; Humberto Nicolini; Danielle Posthuma; Gregory L Hanna; Peter Heutink; Damiaan Denys; Paul D Arnold; Ben A Oostra; Gerald Nestadt; Nelson B Freimer; David L Pauls; Naomi R Wray; S Evelyn Stewart; Carol A Mathews; James A Knowles; Nancy J Cox; Jeremiah M Scharf
Journal:  PLoS Genet       Date:  2013-10-24       Impact factor: 5.917

4.  Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling.

Authors:  Janita Bralten; Joanna Widomska; Barbara Franke; Geert Poelmans; Ward De Witte; Dongmei Yu; Carol A Mathews; Jeremiah M Scharf; Jan Buitelaar; Jennifer Crosbie; Russell Schachar; Paul Arnold; Mathieu Lemire; Christie L Burton
Journal:  Transl Psychiatry       Date:  2020-04-27       Impact factor: 6.222

5.  Genetic and environmental influences on obsessive-compulsive behaviour across development: a longitudinal twin study.

Authors:  G Krebs; M A Waszczuk; H M S Zavos; D Bolton; T C Eley
Journal:  Psychol Med       Date:  2014-12-12       Impact factor: 7.723

6.  Cross-Disorder Genetic Analysis of Tic Disorders, Obsessive-Compulsive, and Hoarding Symptoms.

Authors:  Nuno R Zilhão; Dirk J Smit; Dorret I Boomsma; Danielle C Cath
Journal:  Front Psychiatry       Date:  2016-06-30       Impact factor: 4.157

Review 7.  Genetics of obsessive-compulsive disorder.

Authors:  Behrang Mahjani; Katharina Bey; Julia Boberg; Christie Burton
Journal:  Psychol Med       Date:  2021-05-25       Impact factor: 7.723
  7 in total

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