| Literature DB >> 19803477 |
Yue Qi Ye1, Hiroyuki Koshino, Jun-ichi Onose, Kunie Yoshikawa, Naoki Abe, Shunya Takahashi.
Abstract
A first total synthesis of vialinin B, a powerful inhibitor (IC(50) 20 pM) of TNF-alpha production, is described. The key reactions include a double Suzuki-Miyaura coupling of electron-rich aryl bromide with a couple of phenylboronic acids, a Cu-mediated Ullmann reaction, and a LHMDS-promoted phenylacetylation. This synthesis proceeded in 11 steps with 18% overall yield from a known sesamol derivative.Entities:
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Year: 2009 PMID： 19803477 DOI： 10.1021/ol9020833
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005