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Literature DB >> 19803473

Nanolobatolide, a new C18 metabolite from the Formosan soft coral Sinularia nanolobata.

Yen-Ju Tseng¹, Zhi-Hong Wen, Chang-Feng Dai, Michael Y Chiang, Jyh-Horng Sheu.

Abstract

Nanolobatolide (1), possessing a novel C(18) molecular structure, was isolated from the Formosan soft coral Sinularia nanolobata. The structure of 1 was established by extensive spectroscopic study and confirmed by X-ray diffraction analysis. A plausible biosynthetic pathway of 1 was proposed. Nanolobatolide (1) has been found to possess significant anti-neuroinflammatory and neuroprotective activities.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2009 PMID： 19803473 DOI： 10.1021/ol901990c

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

6 in total

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3. Inhibitory effect of dihydroaustrasulfone alcohol on the migration of human non-small cell lung carcinoma A549 cells and the antitumor effect on a Lewis lung carcinoma-bearing tumor model in C57BL/6J mice.

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Journal: Mar Drugs Date: 2014-01-09 Impact factor: 5.118

Nanolobatolide, a new C18 metabolite from the Formosan soft coral Sinularia nanolobata.

1. Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells.

Review 2. Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action.

3. Inhibitory effect of dihydroaustrasulfone alcohol on the migration of human non-small cell lung carcinoma A549 cells and the antitumor effect on a Lewis lung carcinoma-bearing tumor model in C57BL/6J mice.

4. Bioactive marine drugs and marine biomaterials for brain diseases.

5. Xeniaphyllane-Derived Terpenoids from Soft Coral Sinularia nanolobata.

6. Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata.