Literature DB >> 1980296

The in-situ absorption of antipyrine as a measure of intestinal blood flow in Fluosol-DA haemodiluted rats.

R P Shrewsbury1, L G White.   

Abstract

The effect of moderate Fluosol-DA haemodilution on intestinal blood flow has been investigated in the rat. Antipyrine in-situ intestinal absorption is blood flow limited, and did not alter 0.5, 24, 48, or 72 h after haemodilution with 40 mL kg-1 Fluosol. Thus the intestinal blood flow rate is maintained as part of the physiological response to ensure adequate perfusion of the vital organ.

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Year:  1990        PMID: 1980296     DOI: 10.1111/j.2042-7158.1990.tb06608.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN: 0022-3573            Impact factor:   3.765


  2 in total

1.  Absorption of D-glucose in the rat studied using in situ intestinal perfusion: a permeability-index approach.

Authors:  Y Wang; R Aun; F L Tse
Journal:  Pharm Res       Date:  1997-11       Impact factor: 4.200

2.  Kinetic analysis of the drug permeation process across the intestinal epithelium.

Authors:  S Yamashita; M Yoshida; Y Taki; T Sakane; T Nadai
Journal:  Pharm Res       Date:  1994-11       Impact factor: 4.200

  2 in total

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