| Literature DB >> 1980286 |
R Kravtzoff1, C Ropars, M Laguerre, J P Muh, M Chassaigne.
Abstract
L-Asparaginase has been encapsulated in Swiss mouse or human erythrocytes by hypotonic haemolysis followed by isotonic resealing and reannealing. The details of incorporation and properties of carrier erythrocytes are presented. When L-asparaginase loaded into 51Cr-labelled erythrocytes, was infused intravenously, the same half-life was found for asparaginase and 51Cr. In addition, L-asparaginase loaded into erythrocytes was much more effective in eliminating plasma asparagine compared with the same dose of free L-asparaginase injected in solution, during a sustained period (14 days).Entities:
Mesh：
Substances：
Year: 1990 PMID： 1980286 DOI： 10.1111/j.2042-7158.1990.tb06598.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765