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Literature DB >> 1980282

Inhibitory effect of the somatostatin analog octreotide on rat pituitary tumor cell (GH3) proliferation in vitro.

G Pelicci¹, M C Pagliacci, L Lanfrancone, P G Pelicci, F Grignani, I Nicoletti.

Abstract

The effects of somatostatin-14 (SS-14) and the somatostatin-analog octreotide (SMS 201-995, Sandostatin) on proliferation of GH3 pituitary tumor cells were investigated in vitro. SMS 201-995 exerted a significant, but transient, inhibition on GH3 cell growth which reached a maximum at 24 h and was no longer detectable at 48 h. The concentration that evoked the strongest inhibitory effect was 10 nM SMS 201-995, while lower and higher doses resulted in a less pronounced effect. The inhibitory effect SMS 201-995 exerted on cell proliferation was associated with a dose- and time-related reduction in both c-myc and c-fos mRNA levels. SS-14 had no noteworthy influence on either cell proliferation or c-myc and c-fos protooncogene expression. These data demonstrate that SS-analogs transiently inhibit pituitary tumor cell proliferation in vitro.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Somatostatin
Octreotide

Year: 1990 PMID： 1980282 DOI： 10.1007/bf03349589

Source DB: PubMed Journal: J Endocrinol Invest ISSN： 0391-4097 Impact factor: 4.256

21 in total

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Authors: T Reisine; J Axelrod
Journal: Endocrinology Date: 1983-08 Impact factor: 4.736

4. SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action.

Authors: W Bauer; U Briner; W Doepfner; R Haller; R Huguenin; P Marbach; T J Petcher
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Authors: A V Schally
Journal: Cancer Res Date: 1988-12-15 Impact factor: 12.701

6. Direct inhibitory effects of somatostatin (analogues) on the growth of human breast cancer cells.

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7. Somatostatin analogues inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase.

Authors: C Liebow; C Reilly; M Serrano; A V Schally
Journal: Proc Natl Acad Sci U S A Date: 1989-03 Impact factor: 11.205

8. Direct inhibitory effects of a somatostatin analog, SMS 201-995, on AR4-2J cell proliferation via pertussis toxin-sensitive guanosine triphosphate-binding protein-independent mechanism.

Authors: N Viguerie; N Tahiri-Jouti; A M Ayral; C Cambillau; J L Scemama; M J Bastié; S Knuhtsen; J P Estève; L Pradayrol; C Susini
Journal: Endocrinology Date: 1989-02 Impact factor: 4.736

Inhibitory effect of the somatostatin analog octreotide on rat pituitary tumor cell (GH3) proliferation in vitro.

1. Hypothalamic regulatory hormones.

2. Can inhibition of hormone secretion be associated with endocrine tumour shrinkage?

3. Prolonged somatostatin pretreatment desensitizes somatostatin's inhibition of receptor-mediated release of adrenocorticotropin hormone and sensitizes adenylate cyclase.

4. SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action.

Review 5. Oncological applications of somatostatin analogues.

6. Direct inhibitory effects of somatostatin (analogues) on the growth of human breast cancer cells.

7. Somatostatin analogues inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase.

8. Direct inhibitory effects of a somatostatin analog, SMS 201-995, on AR4-2J cell proliferation via pertussis toxin-sensitive guanosine triphosphate-binding protein-independent mechanism.

9. Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor.

10. Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas.

Review 1. Genetic basis of pituitary adenoma invasiveness: a review.

Review 2. Role of transcription factors in the pathogenesis of pituitary adenomas: a review.

3. Expression and clinical significance of Wnt players and survivin in pituitary tumours.

4. Long-term effects of somatostatin analogues in rat GH-secreting pituitary tumor cell lines.