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Literature DB >> 19802705

Monosomy for the X chromosome.

Abstract

Dosage compensation serves to equalize X chromosome gene expression in mammalian males and females and involves extensive silencing of the 2nd X chromosome in females. If dosage compensation mechanisms completely suppressed the 2nd X chromosome, then actual physical loss of this "eXtra" chromosome should have few consequences. However, X monosomy has major effects upon normal development, fertility and longevity in humans and some other species. This article reviews observations and arguments attempting to explain the phenotypic effects of X monosomy in humans and other mammals in terms of X chromosome gene dosage.

Entities: Species

Mesh：

Year: 2009 PMID： 19802705 DOI： 10.1007/s10577-009-9052-z

Source DB: PubMed Journal: Chromosome Res ISSN： 0967-3849 Impact factor: 5.239

56 in total

1. The influence of parental origin of X chromosome genes on the stature of patients with 45 X Turner syndrome.

Authors: C Kochi; C A Longui; S H V Lemos-Marini; G Guerra-Junior; M B Melo; L E P Calliari; O Monte
Journal: Genet Mol Res Date: 2007-01-18

2. X chromosome gene expression in human tissues: male and female comparisons.

Authors: Zohreh Talebizadeh; Stephen D Simon; Merlin G Butler
Journal: Genomics Date: 2006-09-01 Impact factor: 5.736

3. Zfx controls the self-renewal of embryonic and hematopoietic stem cells.

Authors: Jose M Galan-Caridad; Sivan Harel; Teresita L Arenzana; Z Esther Hou; Fiona K Doetsch; Leonid A Mirny; Boris Reizis
Journal: Cell Date: 2007-04-20 Impact factor: 41.582

4. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.

Authors: Karl Agger; Paul A C Cloos; Jesper Christensen; Diego Pasini; Simon Rose; Juri Rappsilber; Irina Issaeva; Eli Canaani; Anna Elisabetta Salcini; Kristian Helin
Journal: Nature Date: 2007-08-22 Impact factor: 49.962

5. Differential and correlation analyses of microarray gene expression data in the CEPH Utah families.

Authors: Qihua Tan; Jinghua Zhao; Shuxia Li; Lene Christiansen; Torben A Kruse; Kaare Christensen
Journal: Genomics Date: 2008-06-02 Impact factor: 5.736

6. X-inactivation profile reveals extensive variability in X-linked gene expression in females.

Authors: Laura Carrel; Huntington F Willard
Journal: Nature Date: 2005-03-17 Impact factor: 49.962

7. Incidence and spectrum of chromosome abnormalities in spontaneous abortions: new insights from a 12-year study.

Authors: Joshua Menasha; Brynn Levy; Kurt Hirschhorn; Nataline B Kardon
Journal: Genet Med Date: 2005-04 Impact factor: 8.822

8. Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes.

Authors: Ian W Craig; Jonathan Mill; Gavin M Craig; Caroline Loat; Leonard C Schalkwyk
Journal: Eur J Hum Genet Date: 2004-08 Impact factor: 4.246

Review 9. Introduction to the study of pre- and postnatal growth in humans: a review.

Authors: H Mendez
Journal: Am J Med Genet Date: 1985-01

10. Zfx mutation results in small animal size and reduced germ cell number in male and female mice.

Authors: S W Luoh; P A Bain; R D Polakiewicz; M L Goodheart; H Gardner; R Jaenisch; D C Page
Journal: Development Date: 1997-06 Impact factor: 6.868

13 in total

1. Abnormal motor cortex excitability is associated with reduced cortical thickness in X monosomy.

Authors: Jean-François Lepage; Cédric Clouchoux; Maryse Lassonde; Alan C Evans; Cheri L Deal; Hugo Théoret
Journal: Hum Brain Mapp Date: 2011-11-18 Impact factor: 5.038

2. Human gene copy number spectra analysis in congenital heart malformations.

Authors: Aoy Tomita-Mitchell; Donna K Mahnke; Craig A Struble; Maureen E Tuffnell; Karl D Stamm; Mats Hidestrand; Susan E Harris; Mary A Goetsch; Pippa M Simpson; David P Bick; Ulrich Broeckel; Andrew N Pelech; James S Tweddell; Michael E Mitchell
Journal: Physiol Genomics Date: 2012-02-07 Impact factor: 3.107

3. Allele-specific distribution of RNA polymerase II on female X chromosomes.

Authors: Katerina S Kucera; Timothy E Reddy; Florencia Pauli; Jason Gertz; Jenae E Logan; Richard M Myers; Huntington F Willard
Journal: Hum Mol Genet Date: 2011-07-26 Impact factor: 6.150

4. Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency.

Authors: Vladimir K Bakalov; Liat Gutin; Clara M Cheng; Jian Zhou; Puja Sheth; Kavita Shah; Sruthi Arepalli; Vien Vanderhoof; Lawrence M Nelson; Carolyn A Bondy
Journal: J Autoimmun Date: 2012-02-18 Impact factor: 7.094

Review 5. The X chromosome in immune functions: when a chromosome makes the difference.

Authors: Claude Libert; Lien Dejager; Iris Pinheiro
Journal: Nat Rev Immunol Date: 2010-08 Impact factor: 53.106

Review 6. Sexual dimorphism in autoimmunity.

Authors: Kira Rubtsova; Philippa Marrack; Anatoly V Rubtsov
Journal: J Clin Invest Date: 2015-04-27 Impact factor: 14.808

Review 10. Epigenetics in Turner syndrome.

Authors: Francisco Álvarez-Nava; Roberto Lanes
Journal: Clin Epigenetics Date: 2018-04-06 Impact factor: 6.551