Literature DB >> 19802367

Synthesis of Oxadiazole-2-oxide Analogues as Potential Antischistosomal Agents.

Ganesha Rai1, Craig J Thomas, William Leister, David J Maloney.   

Abstract

The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and anti-schistosomal activity.

Entities:  

Year:  2009        PMID： 19802367      PMCID： PMC2721338          DOI： 10.1016/j.tetlet.2009.01.120

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  16 in total

1.  Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Authors:  James Inglese; Douglas S Auld; Ajit Jadhav; Ronald L Johnson; Anton Simeonov; Adam Yasgar; Wei Zheng; Christopher P Austin
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-24       Impact factor: 11.205

2.  A case of refractory schistosomiasis.

Authors:  S Q Murray-Smith; B J Scott; D P Barton; P Weinstein
Journal:  Med J Aust       Date:  1996-10-21       Impact factor: 7.738

3.  The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase.

Authors:  Heather M Alger; David L Williams
Journal:  Mol Biochem Parasitol       Date:  2002-04-30       Impact factor: 1.759

4.  Furoxan analogues of the histamine H3-receptor antagonist imoproxifan and related furazan derivatives.

Authors:  Paolo Tosco; Massimo Bertinaria; Antonella Di Stilo; Clara Cena; Giovanni Sorba; Roberta Fruttero; Alberto Gasco
Journal:  Bioorg Med Chem       Date:  2005-08-01       Impact factor: 3.641

5.  Palladium-imidazolium carbene catalyzed aryl, vinyl, and alkyl Suzuki-Miyaura cross coupling.

Authors:  M B Andrus; C Song
Journal:  Org Lett       Date:  2001-11-15       Impact factor: 6.005

6.  Identification of oxadiazoles as new drug leads for the control of schistosomiasis.

Authors:  Ahmed A Sayed; Anton Simeonov; Craig J Thomas; James Inglese; Christopher P Austin; David L Williams
Journal:  Nat Med       Date:  2008-03-16       Impact factor: 53.440

7.  Furoxans as nitric oxide donors. 4-Phenyl-3-furoxancarbonitrile: thiol-mediated nitric oxide release and biological evaluation.

Authors:  C Medana; G Ermondi; R Fruttero; A Di Stilo; C Ferretti; A Gasco
Journal:  J Med Chem       Date:  1994-12-09       Impact factor: 7.446

8.  Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa.

Authors:  Marieke J van der Werf; Sake J de Vlas; Simon Brooker; Caspar W N Looman; Nico J D Nagelkerke; J Dik F Habbema; Dirk Engels
Journal:  Acta Trop       Date:  2003-05       Impact factor: 3.112

9.  O-TBS-N-tosylhydroxylamine: a reagent for facile conversion of alcohols to oximes.

Authors:  Katsushi Kitahara; Tatsuya Toma; Jun Shimokawa; Tohru Fukuyama
Journal:  Org Lett       Date:  2008-04-30       Impact factor: 6.005

10.  Persistence of Schistosoma haematobium infection despite multiple courses of therapy with praziquantel.

Authors:  B L Herwaldt; L F Tao; W van Pelt; V C Tsang; J I Bruce
Journal:  Clin Infect Dis       Date:  1995-02       Impact factor: 9.079
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  7 in total

1.  Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.

Authors:  Ganesha Rai; Ahmed A Sayed; Wendy A Lea; Hans F Luecke; Harinath Chakrapani; Stefanie Prast-Nielsen; Ajit Jadhav; William Leister; Min Shen; James Inglese; Christopher P Austin; Larry Keefer; Elias S J Arnér; Anton Simeonov; David J Maloney; David L Williams; Craig J Thomas
Journal:  J Med Chem       Date:  2009-10-22       Impact factor: 7.446

2.  A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().

Authors:  Bryan T Mott; Ken Chih-Chien Cheng; Rajarshi Guha; Valerie P Kommer; David L Williams; Jon J Vermeire; Michael Cappello; David J Maloney; Ganesha Rai; Ajit Jadhav; Anton Simeonov; James Inglese; Gary H Posner; Craig J Thomas
Journal:  Medchemcomm       Date:  2012-12       Impact factor: 3.597

3.  New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni.

Authors:  Stefano Guglielmo; Daniela Cortese; Francesca Vottero; Barbara Rolando; Valerie P Kommer; David L Williams; Roberta Fruttero; Alberto Gasco
Journal:  Eur J Med Chem       Date:  2014-07-03       Impact factor: 6.514

4.  Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites.

Authors:  Fabiana Ross; Paola Hernández; Williams Porcal; Gloria V López; Hugo Cerecetto; Mercedes González; Tatiana Basika; Carlos Carmona; Martín Fló; Gabriela Maggioli; Mariana Bonilla; Vadim N Gladyshev; Mariana Boiani; Gustavo Salinas
Journal:  PLoS One       Date:  2012-04-20       Impact factor: 3.240

Review 5.  Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs - biological activities and SAR studies.

Authors:  Banoth Karan Kumar; Kondapalli Venkata Gowri Chandra Sekhar; Subhash Chander; Selvaraj Kunjiappan; Sankaranarayanan Murugesan
Journal:  RSC Adv       Date:  2021-03-29       Impact factor: 4.036

6.  Molecular docking to explore the possible binding mode of potential inhibitors of thioredoxin glutathione reductase.

Authors:  Jingwei Huang; Weijuan Hua; Jiahuang Li; Zichun Hua
Journal:  Mol Med Rep       Date:  2015-07-27       Impact factor: 2.952

7.  Synthesis of bicyclic 1,4-thiazepines as novel anti-Trypanosoma brucei brucei agents.

Authors:  Franco Vairoletti; Andrea Medeiros; Pablo Fontán; Jennifer Meléndrez; Carlos Tabárez; Gustavo Salinas; Jaime Franco; Marcelo A Comini; Jenny Saldaña; Vojtech Jancik; Graciela Mahler; Cecilia Saiz
Journal:  Medchemcomm       Date:  2019-06-11       Impact factor: 3.597
  7 in total

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