Literature DB >> 1980074

Differential regulation of human cardiac beta-adrenergic and muscarinic receptors by chronic beta-adrenoceptor antagonist treatment.

S Motomura1, N M Deighton, H R Zerkowski, M Khamssi, O E Brodde.   

Abstract

In patients undergoing coronary artery bypass grafting chronic beta 1-adrenoceptor antagonist treatment increased right atrial beta 1-adrenoceptor number, did not affect beta 2-adrenoceptor number and decreased muscarinic M2-receptor number. Concomitantly, the M2-receptor-mediated negative inotropic effect of carbachol was reduced, while the beta 1-adrenoceptor-mediated positive inotropic effect of noradrenaline was not altered. The beta 2- adrenoceptor mediated positive inotropic effect of procaterol, however, was markedly enhanced. We conclude that chronic beta 1-adrenoceptor antagonist treatment increases beta 1-adrenoceptor number, sensitizes beta 2-adrenoceptor function and desensitizes M2-receptor function in the human heart.

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Year:  1990        PMID： 1980074      PMCID： PMC1368108          DOI： 10.1111/j.1365-2125.1990.tb05478.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  8 in total

1.  Selective regulation of beta 1- and beta 2-adrenoceptors in the human heart by chronic beta-adrenoceptor antagonist treatment.

Authors:  M C Michel; A Pingsmann; J J Beckeringh; H R Zerkowski; N Doetsch; O E Brodde
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

2.  Adrenoceptor blocking drugs: clinical pharmacology and therapeutic use.

Authors:  D G McDevitt
Journal:  Drugs       Date:  1979-04       Impact factor: 9.546

3.  A comparison of the effects of adrenaline and noradrenaline on human heart: the role of beta 1- and beta 2-adrenoceptors in the stimulation of adenylate cyclase and contractile force.

Authors:  A J Kaumann; J A Hall; K J Murray; F C Wells; M J Brown
Journal:  Eur Heart J       Date:  1989-06       Impact factor: 29.983

4.  Muscarinic cholinoceptors in the human heart: demonstration, subclassification, and distribution.

Authors:  N M Deighton; S Motomura; D Borquez; H R Zerkowski; N Doetsch; O E Brodde
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990 Jan-Feb       Impact factor: 3.000

5.  Beta-adrenoceptor changes in blood lymphocytes and altered drug responsiveness.

Authors:  O E Brodde; X L Wang
Journal:  Ann Clin Res       Date:  1988

Review 6.  The beta-adrenergic blockade withdrawal phenomenon.

Authors:  B N Prichard; B Tomlinson; R J Walden; P Bhattacharjee
Journal:  J Cardiovasc Pharmacol       Date:  1983       Impact factor: 3.105

7.  Mechanism of noradrenaline-induced heterologous desensitization of adenylate cyclase stimulation in rat heart muscle cells: increase in the level of inhibitory G-protein alpha-subunits.

Authors:  C Reithmann; P Gierschik; D Sidiropoulos; K Werdan; K H Jakobs
Journal:  Eur J Pharmacol       Date:  1989-08-15       Impact factor: 4.432

8.  Myocardial beta-adrenoceptor changes in heart failure: concomitant reduction in beta 1- and beta 2-adrenoceptor function related to the degree of heart failure in patients with mitral valve disease.

Authors:  O E Brodde; H R Zerkowski; N Doetsch; S Motomura; M Khamssi; M C Michel
Journal:  J Am Coll Cardiol       Date:  1989-08       Impact factor: 24.094
  8 in total
  1 in total

1.  Characterization of beta(1)-selectivity, adrenoceptor-G(s)-protein interaction and inverse agonism of nebivolol in human myocardium.

Authors:  C Maack; S Tyroller; P Schnabel; B Cremers; E Dabew; M Südkamp; M Böhm
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739
  1 in total

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