BACKGROUND: Evidence supports single-dose preoperative antibiotic (ABX) prophylaxis for breast surgery; however, limited data exist regarding the incidence and type of antibiotic complications postoperatively. METHODS: Breast/axillary surgeries between July 2004 and June 2006 were reviewed. Complications were analyzed by antibiotic group: preoperative prophylaxis, postoperative prophylaxis, and therapeutic intent. The Fisher exact test was used to compare complication rates. RESULTS: A total of 389 patients underwent breast/axillary surgeries during the study period. A total of 363 (93%) patients received ABX: 353 (91%) received a single preoperative dose, 91 (23%) received postoperative ABX prophylaxis, and 76 (201%) received ABX for therapeutic intent. Among patients receiving ABX, 15 (4%) had an ABX-related complication. The ABX-related complication rate was significantly higher among those receiving postoperative prophylaxis (5.5%; 5 of 91) compared with those receiving preoperative ABX alone (0%; 0 of 214) (P = .002). CONCLUSIONS: Drug-related complications were uncommon with preoperative ABX prophylaxis. Considering the potential complications of ABX after breast surgery, the use of postoperative prophylaxis should be reexamined.
BACKGROUND: Evidence supports single-dose preoperative antibiotic (ABX) prophylaxis for breast surgery; however, limited data exist regarding the incidence and type of antibiotic complications postoperatively. METHODS: Breast/axillary surgeries between July 2004 and June 2006 were reviewed. Complications were analyzed by antibiotic group: preoperative prophylaxis, postoperative prophylaxis, and therapeutic intent. The Fisher exact test was used to compare complication rates. RESULTS: A total of 389 patients underwent breast/axillary surgeries during the study period. A total of 363 (93%) patients received ABX: 353 (91%) received a single preoperative dose, 91 (23%) received postoperative ABX prophylaxis, and 76 (201%) received ABX for therapeutic intent. Among patients receiving ABX, 15 (4%) had an ABX-related complication. The ABX-related complication rate was significantly higher among those receiving postoperative prophylaxis (5.5%; 5 of 91) compared with those receiving preoperative ABX alone (0%; 0 of 214) (P = .002). CONCLUSIONS: Drug-related complications were uncommon with preoperative ABX prophylaxis. Considering the potential complications of ABX after breast surgery, the use of postoperative prophylaxis should be reexamined.
Authors: Amy C Degnim; Alyssa D Throckmorton; Sarah Y Boostrom; Judy C Boughey; Andrea Holifield; Larry M Baddour; Tanya L Hoskin Journal: Ann Surg Oncol Date: 2012-06-26 Impact factor: 5.344
Authors: Amy C Degnim; Tanya L Hoskin; Rushin D Brahmbhatt; Anne Warren-Peled; Margie Loprinzi; Emily S Pavey; Judy C Boughey; Tina J Hieken; Steven Jacobson; Valerie Lemaine; James W Jakub; Chetan Irwin; Robert D Foster; Hani Sbitany; Michel Saint-Cyr; Erin Duralde; Sheri Ramaker; Robin Chin; Monica Sieg; Melissa Wildeman; Jeffrey S Scow; Robin Patel; Karla Ballman; Larry M Baddour; Laura J Esserman Journal: Ann Surg Oncol Date: 2014-08-06 Impact factor: 5.344
Authors: Kristin Sandrowski; David Edelman; Michael Rivlin; Christopher Jones; Mark Wang; Gregory Gallant; Pedro K Beredjiklian Journal: Hand (N Y) Date: 2018-07-15
Authors: Amy C Degnim; Jeffrey S Scow; Tanya L Hoskin; Joyce P Miller; Margie Loprinzi; Judy C Boughey; James W Jakub; Alyssa Throckmorton; Robin Patel; Larry M Baddour Journal: Ann Surg Date: 2013-08 Impact factor: 12.969