| Literature DB >> 19800230 |
Andrea L Jochim1, Stephen E Miller, Nicholas G Angelo, Paramjit S Arora.
Abstract
Proteases typically recognize their peptide substrates in extended conformations. General approaches for designing protease inhibitors often consist of peptidomimetics that feature this conformation. Herein we discuss a combination of computational and experimental studies to evaluate the potential of triazole-linked beta-strand mimetics as inhibitors of HIV-1 protease activity.Entities:
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Year: 2009 PMID： 19800230 DOI： 10.1016/j.bmcl.2009.09.049
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823