Yuanhao Xu1, Sabatino Ventura. 1. Prostate Research Co-operative, Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Abstract
AIM OF THE STUDY: To assess the effectiveness of the traditional Chinese herb Phellodendron amurense in treating urological disorders. MATERIALS AND METHODS: Prostate smooth muscle relaxant activity of an extract from the bark of Phellodendron amurense was tested on contractions of isolated rat prostate gland induced by electrical nerve stimulation and direct muscle stimulation. RESULTS: Electrical field stimulation (0.5 ms, 60V, 1-20 Hz) induced nerve mediated contractions of isolated rat prostate were inhibited by Phellodendron amurense extract dissolved in either dimethylsulfoxide (DMSO), acetic acid or water (P<or=0.022, n=6 for each) but not boiling water (P=0.619, n=6). Phellodendron amurense extract also inhibited contractions of isolated rat prostates elicited by exogenous administration of noradrenaline (10nM to 100 microM), acetylcholine (10nM to 100 microM) or adenosine 5'-triphosphate (ATP, 100 nM to 100 microM) (P<or=0.004, n=6-8 for each). CONCLUSION: Phellodendron amurense is able to inhibit prostatic contractility suggesting that it may be useful in the treatment of urological disorders caused by prostatic urethral obstruction such as in the case of benign prostatic hyperplasia (BPH). Crown Copyright 2009. Published by Elsevier Ireland Ltd. All rights reserved.
AIM OF THE STUDY: To assess the effectiveness of the traditional Chinese herb Phellodendron amurense in treating urological disorders. MATERIALS AND METHODS: Prostate smooth muscle relaxant activity of an extract from the bark of Phellodendron amurense was tested on contractions of isolated rat prostate gland induced by electrical nerve stimulation and direct muscle stimulation. RESULTS: Electrical field stimulation (0.5 ms, 60V, 1-20 Hz) induced nerve mediated contractions of isolated rat prostate were inhibited by Phellodendron amurense extract dissolved in either dimethylsulfoxide (DMSO), acetic acid or water (P<or=0.022, n=6 for each) but not boiling water (P=0.619, n=6). Phellodendron amurense extract also inhibited contractions of isolated rat prostates elicited by exogenous administration of noradrenaline (10nM to 100 microM), acetylcholine (10nM to 100 microM) or adenosine 5'-triphosphate (ATP, 100 nM to 100 microM) (P<or=0.004, n=6-8 for each). CONCLUSION:Phellodendron amurense is able to inhibit prostatic contractility suggesting that it may be useful in the treatment of urological disorders caused by prostatic urethral obstruction such as in the case of benign prostatic hyperplasia (BPH). Crown Copyright 2009. Published by Elsevier Ireland Ltd. All rights reserved.
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