[The effect of the simultaneous dopamine- and glutamatergic stimulation of the nucleus accumbens on synaptic dopamine release in the striatum of freely moving rats].

The influence of n. accumbens on the striatal synaptic dopamine release was investigated in freely moving male Sprague-Dawley rats using in vivo intracranial dialysis followed by radioenzymatic analysis. It was shown that amphetamine or glutamic acid dialysis infusion in the n. accumbens resulted in a decrease in striatal extracellular dopamine level while simultaneous infusion of these drugs led to increase in striatal level of extracellular dopamine. It is suggested that there exist an influence of the n. accumbens on dopamine release in the striatum, the sign of this influence being mediated by dopamine-glutamic acid interaction in the n. accumbens.