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Literature DB >> 19798031

Regulatory T cells as therapeutic targets in rheumatoid arthritis.

Jonathan H Esensten¹, David Wofsy, Jeffrey A Bluestone.

Abstract

Regulatory T cells (TREG) are a subset of CD4+ T cells with a critical role in the prevention of autoimmunity. Whether defects in TREG contribute to the pathogenesis of rheumatoid arthritis (RA) is unclear. However, a variety of approved and experimental drugs for RA may work, in part, by promoting the function or increasing numbers of TREG. Furthermore, animal studies demonstrate that direct injection of TREG ameliorates a wide range of experimental models of inflammatory and autoimmune diseases. Thus, cell-based therapy with TREG has the potential to produce durable disease remission in patients with RA.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2009 PMID： 19798031 PMCID： PMC3086064 DOI： 10.1038/nrrheum.2009.183

Source DB: PubMed Journal: Nat Rev Rheumatol ISSN： 1759-4790 Impact factor: 20.543

88 in total

1. Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells.

Authors: Qizhi Tang; Kammi J Henriksen; Elisa K Boden; Aaron J Tooley; Jianqin Ye; Sumit K Subudhi; Xin X Zheng; Terry B Strom; Jeffrey A Bluestone
Journal: J Immunol Date: 2003-10-01 Impact factor: 5.422

2. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors.

Authors: Chyi-Song Hsieh; Yuqiong Liang; Aaron J Tyznik; Steven G Self; Denny Liggitt; Alexander Y Rudensky
Journal: Immunity Date: 2004-08 Impact factor: 31.745

Review 3. Toll-like receptor control of the adaptive immune responses.

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Journal: Nat Immunol Date: 2004-10 Impact factor: 25.606

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Authors: Christian Mottet; Holm H Uhlig; Fiona Powrie
Journal: J Immunol Date: 2003-04-15 Impact factor: 5.422

5. CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid.

Authors: Jocea M R van Amelsfort; Kim M G Jacobs; Johannes W J Bijlsma; Floris P J G Lafeber; Leonie S Taams
Journal: Arthritis Rheum Date: 2004-09

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Authors: John A Snowden; Jakob Passweg; John J Moore; Sam Milliken; Paul Cannell; Jacob Van Laar; Robert Verburg; Jeffrey Szer; Kerry Taylor; David Joske; Simon Rule; Sarah J Bingham; Paul Emery; Richard K Burt; Raymond M Lowenthal; Patrick Durez; Robert J McKendry; Steven Z Pavletic; Ildefonso Espigado; Esa Jantunen; Ashwin Kashyap; Marco Rabusin; Peter Brooks; Christopher Bredeson; Alan Tyndall
Journal: J Rheumatol Date: 2004-03 Impact factor: 4.666

7. Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity.

Authors: I M De Kleer; D M C Brinkman; A Ferster; M Abinun; P Quartier; J Van Der Net; R Ten Cate; L R Wedderburn; G Horneff; J Oppermann; F Zintl; H E Foster; A M Prieur; A Fasth; M A J Van Rossum; W Kuis; N M Wulffraat
Journal: Ann Rheum Dis Date: 2004-10 Impact factor: 19.103

8. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization.

Authors: Ruka Setoguchi; Shohei Hori; Takeshi Takahashi; Shimon Sakaguchi
Journal: J Exp Med Date: 2005-03-07 Impact factor: 14.307

9. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.

Authors: Qizhi Tang; Kammi J Henriksen; Mingying Bi; Erik B Finger; Greg Szot; Jianqin Ye; Emma L Masteller; Hugh McDevitt; Mark Bonyhadi; Jeffrey A Bluestone
Journal: J Exp Med Date: 2004-06-07 Impact factor: 14.307

10. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy.

Authors: Michael R Ehrenstein; Jamie G Evans; Animesh Singh; Samantha Moore; Gary Warnes; David A Isenberg; Claudia Mauri
Journal: J Exp Med Date: 2004-07-26 Impact factor: 14.307

51 in total

1. The expression and distribution of immunomodulatory proteins B7-H1, B7-DC, B7-H3, and B7-H4 in rheumatoid synovium.

Authors: Guoning Guo; Yongjun Shang; Guoyan Zhu; Xiaoren Bao; Shiwei Xu; Yongwen Chen
Journal: Clin Rheumatol Date: 2011-07-22 Impact factor: 2.980

Review 2. Hydrogels and scaffolds for immunomodulation.

Authors: Ankur Singh; Nicholas A Peppas
Journal: Adv Mater Date: 2014-08-25 Impact factor: 30.849

3. Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety.

Authors: Jorge Paz Rodriguez; Michael P Murphy; Soonjun Hong; Marialaura Madrigal; Keith L March; Boris Minev; Robert J Harman; Chien-Shing Chen; Ruben Berrocal Timmons; Annette M Marleau; Neil H Riordan
Journal: Int Arch Med Date: 2012-02-08

4. Oestrogen-mediated protection of experimental autoimmune encephalomyelitis in the absence of Foxp3+ regulatory T cells implicates compensatory pathways including regulatory B cells.

Authors: Sandhya Subramanian; Melissa Yates; Arthur A Vandenbark; Halina Offner
Journal: Immunology Date: 2010-11-23 Impact factor: 7.397

5. Enhanced suppressive function of regulatory T cells from patients with immune-mediated diseases following successful ex vivo expansion.

Authors: Tinghua Cao; Sally E Wenzel; William A Faubion; Gregory Harriman; Li Li
Journal: Clin Immunol Date: 2010-05-15 Impact factor: 3.969