Literature DB >> 19797318

Another facet of ubiquitylation: death.

W Wei-Lynn Wong1, John Silke.   

Abstract

Ubiquitylation of caspase-8 by the Cullin3 E3 ligase allows its translocation to cytosolic aggregates in the cell by p62/sequestosome-1, increasing caspase-8 activation and thus leading to TRAIL-induced cell death.

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Year:  2009        PMID： 19797318     DOI： 10.1093/jmcb/mjp019

Source DB:  PubMed          Journal:  J Mol Cell Biol        ISSN： 1759-4685            Impact factor:   6.216


  2 in total

1.  p62/SQSTM1 as an oncotarget mediates cisplatin resistance through activating RIP1-NF-κB pathway in human ovarian cancer cells.

Authors:  Xiao-Yu Yan; Yu Zhang; Juan-Juan Zhang; Li-Chao Zhang; Ya-Nan Liu; Yao Wu; Ya-Nan Xue; Sheng-Yao Lu; Jing Su; Lian-Kun Sun
Journal:  Cancer Sci       Date:  2017-06-25       Impact factor: 6.716

2.  Human β-defensin-3 reduces excessive autophagy in intestinal epithelial cells and in experimental necrotizing enterocolitis.

Authors:  Liping Chen; Zhibao Lv; Zhimei Gao; Guijie Ge; Xueli Wang; Junmei Zhou; Qingfeng Sheng
Journal:  Sci Rep       Date:  2019-12-27       Impact factor: 4.379
  2 in total

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