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Literature DB >> 19797314

A little 'help' from IL-21 during persistent viral infection.

Abstract

Anti-viral CD4(+) T cells are required to orchestrate and sustain the activities of the adaptive immune system during a persistent viral infection. Three recent studies suggest that CD4(+) T cells accomplish this in part through the release of IL-21.

Entities: Disease Gene

Mesh：

Substances：

Year: 2009 PMID： 19797314 PMCID： PMC2905061 DOI： 10.1093/jmcb/mjp021

Source DB: PubMed Journal: J Mol Cell Biol ISSN： 1759-4685 Impact factor: 6.216

15 in total

Review 1. Redefining chronic viral infection.

Authors: Herbert W Virgin; E John Wherry; Rafi Ahmed
Journal: Cell Date: 2009-07-10 Impact factor: 41.582

2. Interleukin-10 determines viral clearance or persistence in vivo.

Authors: David G Brooks; Matthew J Trifilo; Kurt H Edelmann; Luc Teyton; Dorian B McGavern; Michael B A Oldstone
Journal: Nat Med Date: 2006-10-15 Impact factor: 53.440

3. Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection.

Authors: David G Brooks; Luc Teyton; Michael B A Oldstone; Dorian B McGavern
Journal: J Virol Date: 2005-08 Impact factor: 5.103

4. Restoring function in exhausted CD8 T cells during chronic viral infection.

Authors: Daniel L Barber; E John Wherry; David Masopust; Baogong Zhu; James P Allison; Arlene H Sharpe; Gordon J Freeman; Rafi Ahmed
Journal: Nature Date: 2005-12-28 Impact factor: 49.962

5. CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection.

Authors: M Matloubian; R J Concepcion; R Ahmed
Journal: J Virol Date: 1994-12 Impact factor: 5.103

Review 6. Interleukin-21: basic biology and implications for cancer and autoimmunity.

Authors: Rosanne Spolski; Warren J Leonard
Journal: Annu Rev Immunol Date: 2008 Impact factor: 28.527

7. Viral immune evasion due to persistence of activated T cells without effector function.

Authors: A J Zajac; J N Blattman; K Murali-Krishna; D J Sourdive; M Suresh; J D Altman; R Ahmed
Journal: J Exp Med Date: 1998-12-21 Impact factor: 14.307

8. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

Authors: Shawn D Blackburn; Haina Shin; W Nicholas Haining; Tao Zou; Creg J Workman; Antonio Polley; Michael R Betts; Gordon J Freeman; Dario A A Vignali; E John Wherry
Journal: Nat Immunol Date: 2008-11-30 Impact factor: 25.606

9. Enhancing SIV-specific immunity in vivo by PD-1 blockade.

Authors: Vijayakumar Velu; Kehmia Titanji; Baogong Zhu; Sajid Husain; Annette Pladevega; Lilin Lai; Thomas H Vanderford; Lakshmi Chennareddi; Guido Silvestri; Gordon J Freeman; Rafi Ahmed; Rama Rao Amara
Journal: Nature Date: 2008-12-10 Impact factor: 49.962