Literature DB >> 19797267

STAT3 revs up the powerhouse.

Nancy C Reich1.   

Abstract

Tyrosine phosphorylation of signal transducers and activators of transcription (STATs) promotes their dimerization and ability to bind target genes in the nucleus. However, evidence shows that one member of the STAT family, STAT3, has an additional property independent of its classical role in the nucleus. STAT3 modifed by serine phosphorylation augmented oxidative phosphorylation in mitochondria and supported cellular transformation by oncogenic Ras.

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Year:  2009        PMID： 19797267     DOI： 10.1126/scisignal.290pe61

Source DB:  PubMed          Journal:  Sci Signal        ISSN： 1945-0877            Impact factor:   8.192


  31 in total

1.  Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype.

Authors:  Charlie Mantel; Steven Messina-Graham; Akira Moh; Scott Cooper; Giao Hangoc; Xin-Yuan Fu; Hal E Broxmeyer
Journal:  Blood       Date:  2012-06-04       Impact factor: 22.113

2.  Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival.

Authors:  Jaclynn Levine; Eunice Kwon; Pablo Paez; Weihong Yan; Gregg Czerwieniec; Joseph A Loo; Michael V Sofroniew; Ina-Beate Wanner
Journal:  Glia       Date:  2015-12-19       Impact factor: 7.452

3.  STAT3 inhibition reduces toxicity of oncolytic VSV and provides a potentially synergistic combination therapy for hepatocellular carcinoma.

Authors:  S Marozin; J Altomonte; K A Muñoz-Álvarez; A Rizzani; E N De Toni; W E Thasler; R M Schmid; O Ebert
Journal:  Cancer Gene Ther       Date:  2015-05-01       Impact factor: 5.987

4.  Janus kinase 2/signal transducer and activator of transcription 3 inhibitors attenuate the effect of cardiotrophin-like cytokine factor 1 and human focal segmental glomerulosclerosis serum on glomerular filtration barrier.

Authors:  Mukut Sharma; Jianping Zhou; Jean-François Gauchat; Ram Sharma; Ellen T McCarthy; Tarak Srivastava; Virginia J Savin
Journal:  Transl Res       Date:  2015-03-16       Impact factor: 7.012

5.  Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo.

Authors:  Jiyoung Park; Christine M Kusminski; Streamson C Chua; Philipp E Scherer
Journal:  Am J Pathol       Date:  2010-11-05       Impact factor: 4.307

6.  The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy.

Authors:  H L Grabenstatter; Y Cruz Del Angel; J Carlsen; M F Wempe; A M White; M Cogswell; S J Russek; A R Brooks-Kayal
Journal:  Neurobiol Dis       Date:  2013-09-16       Impact factor: 5.996

Review 7.  Mechanisms for axon maintenance and plasticity in motoneurons: alterations in motoneuron disease.

Authors:  Sibylle Jablonka; Benjamin Dombert; Esther Asan; Michael Sendtner
Journal:  J Anat       Date:  2013-09-06       Impact factor: 2.610

8.  Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue.

Authors:  Diana Whitaker-Menezes; Ubaldo E Martinez-Outschoorn; Neal Flomenberg; Ruth C Birbe; Agnieszka K Witkiewicz; Anthony Howell; Stephanos Pavlides; Aristotelis Tsirigos; Adam Ertel; Richard G Pestell; Paolo Broda; Carlo Minetti; Michael P Lisanti; Federica Sotgia
Journal:  Cell Cycle       Date:  2011-12-01       Impact factor: 4.534

9.  The control of reactive oxygen species production by SHP-1 in oligodendrocytes.

Authors:  Ross C Gruber; Daria LaRocca; Scott B Minchenberg; George P Christophi; Chad A Hudson; Alex K Ray; Bridget Shafit-Zagardo; Paul T Massa
Journal:  Glia       Date:  2015-04-27       Impact factor: 7.452

10.  Activation of Janus kinase/signal transducer and activator of transcription 3 pathway by growth hormone-releasing hormone.

Authors:  Agnieszka Siejka; Andrew V Schally; Nektarios Barabutis
Journal:  Cell Mol Life Sci       Date:  2009-12-13       Impact factor: 9.261
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