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Literature DB >> 19796243

The role of PLZF in human myeloid development.

Abstract

Little is known of the molecular regulators that enable production of large numbers of mature human hematopoietic cells ( approximately 10(12) cells daily) while at the same time ensuring that the progenitor pools are not depleted. At the same time, the system must remain sufficiently flexible to respond to conditions of increased cellular output such as during blood loss or infection. We have identified a key role for the transcription factor PLZF in both these processes.

Entities: Disease Gene Species

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Year: 2009 PMID： 19796243 DOI： 10.1111/j.1749-6632.2009.04965.x

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

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Cited

6 in total

1. Understanding PLZF: two transcriptional targets, REDD1 and smooth muscle α-actin, define new questions in growth control, senescence, self-renewal and tumor suppression.

Authors: Marina Kolesnichenko; Peter K Vogt
Journal: Cell Cycle Date: 2011-03-01 Impact factor: 4.534

2. Promyelocytic leukaemia zinc finger maintains self-renewal of male germline stem cells (mGSCs) and its expression pattern in dairy goat testis.

Authors: W Song; H Zhu; M Li; N Li; J Wu; H Mu; X Yao; W Han; W Liu; J Hua
Journal: Cell Prolif Date: 2013-08 Impact factor: 6.831

3. Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity.

Authors: Myriam Koubi; Mathilde Poplineau; Julien Vernerey; Lia N'Guyen; Guillaume Tiberi; Sylvain Garciaz; Abdessamad El-Kaoutari; Muhammad A Maqbool; Jean-Christophe Andrau; Christel Guillouf; Andrew J Saurin; Estelle Duprez
Journal: Nucleic Acids Res Date: 2018-04-20 Impact factor: 16.971

The role of PLZF in human myeloid development.

1. Understanding PLZF: two transcriptional targets, REDD1 and smooth muscle α-actin, define new questions in growth control, senescence, self-renewal and tumor suppression.

2. Promyelocytic leukaemia zinc finger maintains self-renewal of male germline stem cells (mGSCs) and its expression pattern in dairy goat testis.

3. Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity.

4. Dmrt1 regulates the immune response by repressing the TLR4 signaling pathway in goat male germline stem cells.

5. Inhibitory Potential of Shen-Shuai-Ling Formulation on Renal Interstitial Fibrosis via Upregulation of PLZF.

6. Detection of genomic regions associated malformations in newborn piglets: a machine-learning approach.