Mohammad Bayat1, Afsaneh Azari, Mohammad Ghasem Golmohammadi. 1. Physical Therapy Research Group, Academic Center for Education, Culture, and Research, Iran Medical Science Branch University, Vanak, Tehran, Iran. bayat_m@yahoo.com
Abstract
OBJECTIVE: The aim of the present investigation is to evaluate the effects of a 780-nm low-level laser on open skin wound healing. BACKGROUND DATA: Optimal parameters of low-level laser therapy (LLLT) for wound healing are discussed. METHODS: One full-thickness skin wound was surgically induced in the dorsum skin of 30 rats. The rats were divided into two groups. Rats in the experimental group were daily treated with a gallium aluminum arsenide (GaAlAs) laser (2 J/cm(2), lambda = 780 nm, pulse frequency of 2336 Hz). Rats in the sham-exposed group received LLLT with switched off equipment. After 4, 7, and 15 days, wounds were checked by histological and biomechanical methods. Data were analyzed by the Mann-Whitney U-test. RESULTS: Fibroblasts, endothelium of blood vessels, blood vessel sections, and maximum stress were significantly increased, whereas macrophages were significantly decreased, compared with those of the sham-exposed group. CONCLUSION: Pulsed LLLT with a 780-nm GaAlAs laser significantly accelerates the process of healing of surgically induced, full-thickness skin wounds in rat.
OBJECTIVE: The aim of the present investigation is to evaluate the effects of a 780-nm low-level laser on open skin wound healing. BACKGROUND DATA: Optimal parameters of low-level laser therapy (LLLT) for wound healing are discussed. METHODS: One full-thickness skin wound was surgically induced in the dorsum skin of 30 rats. The rats were divided into two groups. Rats in the experimental group were daily treated with a gallium aluminum arsenide (GaAlAs) laser (2 J/cm(2), lambda = 780 nm, pulse frequency of 2336 Hz). Rats in the sham-exposed group received LLLT with switched off equipment. After 4, 7, and 15 days, wounds were checked by histological and biomechanical methods. Data were analyzed by the Mann-Whitney U-test. RESULTS: Fibroblasts, endothelium of blood vessels, blood vessel sections, and maximum stress were significantly increased, whereas macrophages were significantly decreased, compared with those of the sham-exposed group. CONCLUSION: Pulsed LLLT with a 780-nm GaAlAs laser significantly accelerates the process of healing of surgically induced, full-thickness skin wounds in rat.
Authors: Fernando José Camello de Lima; Olavo Barbosa de Oliveira Neto; Fabiano Timbó Barbosa; Ailton Mota do Nascimento Galvão; Fernando Wagner Silva Ramos; Christiane Calheiros Farias de Lima; Célio Fernando de Sousa Rodrigues Journal: Lasers Med Sci Date: 2016-02-09 Impact factor: 3.161
Authors: Asheesh Gupta; Pinar Avci; Magesh Sadasivam; Rakkiyappan Chandran; Nivaldo Parizotto; Daniela Vecchio; Wanessa C M A de Melo; Tianhong Dai; Long Y Chiang; Michael R Hamblin Journal: Biotechnol Adv Date: 2012-08-21 Impact factor: 14.227