OBJECTIVE: To investigate if anti-Ro/SSA antibody-exposed fetuses with prolonged atrioventricular (AV) time intervals also have prolongation of the isovolumetric contraction time (ICT). METHODS: Seventy-eight anti-Ro/SSA (including 70 anti-Ro52) antibody-exposed fetuses at risk for congenital heart block (CHB) were followed weekly, between 18 and 24 weeks of gestation, with two Doppler echocardiographic methods designed to detect signs of first-degree AV block. One of these AV time measurements, using hemodynamic events from the mitral valve and aortic outflow as indirect markers of atrial and ventricular depolarization (MV-Ao), was also used to calculate a time interval representing an early phase of systolic cardiac performance, i.e. the ICT. Two hundred and eighty-four women with normal pregnancies served as controls for AV time intervals and another 106 were used to establish an ICT reference range. RESULTS: Strong positive relationships were found between ICT and MV-Ao time intervals (r = 0.91, P < 0.001), as well as between ICT and time intervals obtained from the superior vena cava and aorta (r = 0.85, P < 0.001). The ICT was estimated to contribute more than 50% of the total AV time prolongation. Abnormal AV time and ICT intervals were only seen in anti-Ro52 positive pregnancies. CONCLUSIONS: The ICT is an important contributor to prolongation of AV time intervals. This observation suggests that anti-Ro52/SSA antibody-exposed fetal hearts have not only disturbed electrical conduction but also decreased mechanical performance. Moreover, our findings have implications for the interpretation of AV time intervals used for surveillance of fetuses at risk for developing CHB. Copyright (c) 2009 ISUOG. Published by John Wiley & Sons, Ltd.
OBJECTIVE: To investigate if anti-Ro/SSA antibody-exposed fetuses with prolonged atrioventricular (AV) time intervals also have prolongation of the isovolumetric contraction time (ICT). METHODS: Seventy-eight anti-Ro/SSA (including 70 anti-Ro52) antibody-exposed fetuses at risk for congenital heart block (CHB) were followed weekly, between 18 and 24 weeks of gestation, with two Doppler echocardiographic methods designed to detect signs of first-degree AV block. One of these AV time measurements, using hemodynamic events from the mitral valve and aortic outflow as indirect markers of atrial and ventricular depolarization (MV-Ao), was also used to calculate a time interval representing an early phase of systolic cardiac performance, i.e. the ICT. Two hundred and eighty-four women with normal pregnancies served as controls for AV time intervals and another 106 were used to establish an ICT reference range. RESULTS: Strong positive relationships were found between ICT and MV-Ao time intervals (r = 0.91, P < 0.001), as well as between ICT and time intervals obtained from the superior vena cava and aorta (r = 0.85, P < 0.001). The ICT was estimated to contribute more than 50% of the total AV time prolongation. Abnormal AV time and ICT intervals were only seen in anti-Ro52 positive pregnancies. CONCLUSIONS: The ICT is an important contributor to prolongation of AV time intervals. This observation suggests that anti-Ro52/SSA antibody-exposed fetal hearts have not only disturbed electrical conduction but also decreased mechanical performance. Moreover, our findings have implications for the interpretation of AV time intervals used for surveillance of fetuses at risk for developing CHB. Copyright (c) 2009 ISUOG. Published by John Wiley & Sons, Ltd.
Authors: A Hoxha; A Ruffatti; A Ambrosi; V Ottosson; M Hedlund; L Ottosson; M Anandapadamanaban; M Sunnerhagen; S-E Sonesson; M Wahren-Herlenius Journal: Clin Exp Immunol Date: 2016-09-13 Impact factor: 4.330
Authors: Katja E Odening; Henk J van der Linde; Michael J Ackerman; Paul G A Volders; Rachel M A Ter Bekke Journal: Eur Heart J Date: 2022-08-21 Impact factor: 35.855
Authors: Sabrina Meisgen; Malin Hedlund; Aurelie Ambrosi; Lasse Folkersen; Vijole Ottosson; David Forsberg; Gudny Ella Thorlacius; Luca Biavati; Linn Strandberg; Johannes Mofors; Daniel Ramskold; Sabrina Ruhrmann; Lauro Meneghel; William Nyberg; Alexander Espinosa; Robert Murray Hamilton; Anders Franco-Cereceda; Anders Hamsten; Tomas Olsson; Lois Greene; Per Eriksson; Kristina Gemzell-Danielsson; Stina Salomonsson; Vijay K Kuchroo; Eric Herlenius; Ingrid Kockum; Sven-Erik Sonesson; Marie Wahren-Herlenius Journal: Ann Rheum Dis Date: 2022-04-25 Impact factor: 27.973