BACKGROUND: The pattern of brain morphological changes at the early stages of schizophrenia may depend on the age at onset of illness; in children and adolescents with schizophrenia, grey matter deficits are seen in the parietal lobe whereas in individuals with adult onset these are more widespread. AIMS: To examine whether white matter is similarly affected. METHOD: Diffusion tensor imaging was used to compare fractional anisotropy measures in individuals with adolescent-onset (n = 17) and adult-onset schizophrenia (n = 17) with those in age- and gender-matched controls. RESULTS: Compared with their respective controls, individuals with adolescent-onset schizophrenia showed fractional anisotropy decrease in parietal regions; individuals with adult onset showed additional fractional anisotropy reductions in frontal, temporal and cerebellar regions. A differential effect of age at onset (adolescent v. adult) was noted bilaterally in medial prefrontal white matter. CONCLUSIONS: White matter abnormalities in frontal regions in schizophrenia may depend on developmental stage at the time of illness onset.
BACKGROUND: The pattern of brain morphological changes at the early stages of schizophrenia may depend on the age at onset of illness; in children and adolescents with schizophrenia, grey matter deficits are seen in the parietal lobe whereas in individuals with adult onset these are more widespread. AIMS: To examine whether white matter is similarly affected. METHOD: Diffusion tensor imaging was used to compare fractional anisotropy measures in individuals with adolescent-onset (n = 17) and adult-onset schizophrenia (n = 17) with those in age- and gender-matched controls. RESULTS: Compared with their respective controls, individuals with adolescent-onset schizophrenia showed fractional anisotropy decrease in parietal regions; individuals with adult onset showed additional fractional anisotropy reductions in frontal, temporal and cerebellar regions. A differential effect of age at onset (adolescent v. adult) was noted bilaterally in medial prefrontal white matter. CONCLUSIONS:White matter abnormalities in frontal regions in schizophrenia may depend on developmental stage at the time of illness onset.
Authors: S Lui; L Yao; Y Xiao; S K Keedy; J L Reilly; R S Keefe; C A Tamminga; M S Keshavan; G D Pearlson; Q Gong; J A Sweeney Journal: Psychol Med Date: 2014-05-20 Impact factor: 7.723
Authors: Laura Pina-Camacho; Ángel Del Rey-Mejías; Joost Janssen; Miquel Bioque; Ana González-Pinto; Celso Arango; Antonio Lobo; Salvador Sarró; Manuel Desco; Julio Sanjuan; Maria Lacalle-Aurioles; Manuel J Cuesta; Jerónimo Saiz-Ruiz; Miguel Bernardo; Mara Parellada Journal: Schizophr Bull Date: 2015-09-14 Impact factor: 9.306
Authors: Tejas S Bhojraj; Konasale M Prasad; Shaun M Eack; Alan N Francis; Debra M Montrose; Matcheri S Keshavan Journal: Schizophr Res Date: 2010-02-19 Impact factor: 4.939