Literature DB >> 19793901

Cellular targeting of engineered heterologous antigens is a determinant factor for bovine herpesvirus 4-based vaccine vector development.

Gaetano Donofrio1, Valentina Franceschi, Antonio Capocefalo, Simone Taddei, Chiara Sartori, Sabrina Bonomini, Sandro Cavirani, Clotilde S Cabassi, Cesidio F Flammini.   

Abstract

In a previous study, an apathogenic strain of bovine herpesvirus 4 (BoHV-4) cloned as a bacterial artificial chromosome and expressing a chimeric peptide (gE2/gD) as a secreted form was described. Recombinant virus-inoculated animals produced antibodies against bovine viral diarrhea virus (BVDV) gE2 and BoHV-1 gD. However, neutralizing antibodies were produced only against BVDV, not against BoHV-1. In the present work a recombinant BoHV-4 expressing a membrane-linked form of gE2/gD chimeric peptide was constructed, and inoculated rabbits produced serum-neutralizing antibodies against both BVDV and BoHV-1. Protein cell sorting and targeting are a very important issue when immunodominant antigens are engineered for recombinant virus vaccine development.

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Year:  2009        PMID： 19793901      PMCID： PMC2772392          DOI： 10.1128/CVI.00224-09

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  27 in total

1.  Altering the cellular location of an antigen expressed by a DNA-based vaccine modulates the immune response.

Authors:  P J Lewis; L A Babiuk
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

2.  Bovine viral diarrhea virus types 1 and 2 antibody response in calves receiving modified live virus or inactivated vaccines.

Authors:  R W Fulton; L J Burge
Journal:  Vaccine       Date:  2000-09-15       Impact factor: 3.641

3.  Pluripotency of mesenchymal stem cells derived from adult marrow.

Authors:  Yuehua Jiang; Balkrishna N Jahagirdar; R Lee Reinhardt; Robert E Schwartz; C Dirk Keene; Xilma R Ortiz-Gonzalez; Morayma Reyes; Todd Lenvik; Troy Lund; Mark Blackstad; Jingbo Du; Sara Aldrich; Aaron Lisberg; Walter C Low; David A Largaespada; Catherine M Verfaillie
Journal:  Nature       Date:  2002-06-20       Impact factor: 49.962

4.  Potential of bovine herpesvirus 4 as a gene delivery vector.

Authors:  Gaetano Donofrio; Sandro Cavirani; Taddei Simone; Vicky L van Santen
Journal:  J Virol Methods       Date:  2002-03       Impact factor: 2.014

5.  Concurrent respiratory and genital disease associated with infectious bovine rhinotracheitis-infectious pustular vulvo-vaginitis (IBR-IPV) virus in a dairy herd in the United Kingdom.

Authors:  D F Collings; E P Gibbs; L P Stafford
Journal:  Vet Rec       Date:  1972-08-26       Impact factor: 2.695

6.  The immunogenicity and efficacy of replication-defective and replication-competent bovine adenovirus-3 expressing bovine herpesvirus-1 glycoprotein gD in cattle.

Authors:  P S Reddy; N Idamakanti; C Pyne; A N Zakhartchouk; D L Godson; Z Papp; M E Baca-Estrada; L A Babiuk; G K Mutwiri; S K Tikoo
Journal:  Vet Immunol Immunopathol       Date:  2000-10-31       Impact factor: 2.046

Review 7.  The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies.

Authors:  M Fussenegger
Journal:  Biotechnol Prog       Date:  2001 Jan-Feb

8.  Double immunization strategy with a BoHV-4-vectorialized secreted chimeric peptide BVDV-E2/BoHV-1-gD.

Authors:  G Donofrio; C Sartori; V Franceschi; A Capocefalo; S Cavirani; S Taddei; C F Flammini
Journal:  Vaccine       Date:  2008-09-21       Impact factor: 3.641

9.  Interactions of monoclonal antibodies and bovine herpesvirus type 1 (BHV-1) glycoproteins: characterization of their biochemical and immunological properties.

Authors:  S van Drunen Littel-van den Hurk; J V van den Hurk; J E Gilchrist; V Misra; L A Babiuk
Journal:  Virology       Date:  1984-06       Impact factor: 3.616

10.  Studies on the pathogenesis of a bovine cytomegalo-like virus in an experimental host.

Authors:  F A Osorio; D L Rock; D E Reed
Journal:  J Gen Virol       Date:  1985-09       Impact factor: 3.891
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  15 in total

1.  Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer stem cells.

Authors:  Gaetano Donofrio; Giulia Tebaldi; Stefania Lanzardo; Roberto Ruiu; Elisabetta Bolli; Andrea Ballatore; Valeria Rolih; Francesca Macchi; Laura Conti; Federica Cavallo
Journal:  Oncoimmunology       Date:  2018-09-06       Impact factor: 8.110

2.  Herpes simplex virus type 1 thymidine kinase-armed bovine herpesvirus type 4-based vector displays enhanced oncolytic properties in immunocompetent orthotopic syngenic mouse and rat glioma models.

Authors:  Marco Redaelli; Valentina Franceschi; Antonio Capocefalo; Domenico D'Avella; Luca Denaro; Sandro Cavirani; Carla Mucignat-Caretta; Gaetano Donofrio
Journal:  Neuro Oncol       Date:  2012-01-06       Impact factor: 12.300

3.  In vivo image analysis of BoHV-4-based vector in mice.

Authors:  Valentina Franceschi; Fabio Franco Stellari; Carlo Mangia; Sarah Jacca; Sophia Lavrentiadou; Sandro Cavirani; Mathias Heikenwalder; Gaetano Donofrio
Journal:  PLoS One       Date:  2014-04-21       Impact factor: 3.240

4.  Generation and characterization of the first immortalized alpaca cell line suitable for diagnostic and immunization studies.

Authors:  Valentina Franceschi; Sarah Jacca; Elena L Sassu; Fabio F Stellari; Vicky L van Santen; Gaetano Donofrio
Journal:  PLoS One       Date:  2014-08-20       Impact factor: 3.240

5.  BoHV-4-based vector delivering Ebola virus surface glycoprotein.

Authors:  Alfonso Rosamilia; Sarah Jacca; Giulia Tebaldi; Silvia Tiberti; Valentina Franceschi; Francesca Macchi; Sandro Cavirani; Gary Kobinger; Donald P Knowles; Gaetano Donofrio
Journal:  J Transl Med       Date:  2016-11-24       Impact factor: 5.531

6.  Clinical protection of goats against CpHV-1 induced genital disease with a BoHV-4-based vector expressing CpHV-1 gD.

Authors:  Gaetano Donofrio; Valentina Franceschi; Angela Lovero; Antonio Capocefalo; Michele Camero; Michele Losurdo; Sandro Cavirani; Mariarosaria Marinaro; Erika Grandolfo; Canio Buonavoglia; Maria Tempesta
Journal:  PLoS One       Date:  2013-01-03       Impact factor: 3.240

7.  BoHV-4 immediate early 1 gene is a dispensable gene and its product is not a bone marrow stromal cell antigen 2 counteracting factor.

Authors:  Valentina Franceschi; Antonio Capocefalo; Sarah Jacca; Alfonso Rosamilia; Sandro Cavirani; Fengwen Xu; Wentao Qiao; Gaetano Donofrio
Journal:  BMC Vet Res       Date:  2015-08-27       Impact factor: 2.741

8.  BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-/-) Mice from Monkeypoxvirus Lethal Challenge.

Authors:  Valentina Franceschi; Scott Parker; Sarah Jacca; Ryan W Crump; Konstantin Doronin; Edguardo Hembrador; Daniela Pompilio; Giulia Tebaldi; Ryan D Estep; Scott W Wong; Mark R Buller; Gaetano Donofrio
Journal:  PLoS Negl Trop Dis       Date:  2015-06-18

9.  Bovine herpesvirus 4-based vector delivering a hybrid rat/human HER-2 oncoantigen efficiently protects mice from autochthonous Her-2+ mammary cancer.

Authors:  Sarah Jacca; Valeria Rolih; Elena Quaglino; Valentina Franceschi; Giulia Tebaldi; Elisabetta Bolli; Alfonso Rosamilia; Simone Ottonello; Federica Cavallo; Gaetano Donofrio
Journal:  Oncoimmunology       Date:  2015-08-31       Impact factor: 8.110

10.  Induction of Antihuman C-C Chemokine Receptor Type 5 Antibodies by a Bovine Herpesvirus Type-4 Based Vector.

Authors:  Andrea Elizabeth Verna; Valentina Franceschi; Giulia Tebaldi; Francesca Macchi; Valentina Menozzi; Claudia Pastori; Lucia Lopalco; Simone Ottonello; Sandro Cavirani; Gaetano Donofrio
Journal:  Front Immunol       Date:  2017-10-25       Impact factor: 7.561
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