| Literature DB >> 19793335 |
O J Broom1, B Widjaya, J Troelsen, J Olsen, O H Nielsen.
Abstract
Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by the perpetual production of inflammatory mediators. Research into the transduction pathway behind this over-production has highlighted the potential mediating role for the MAPKs and their related signalling components. This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD.Entities:
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Year: 2009 PMID： 19793335 PMCID： PMC2792822 DOI： 10.1111/j.1365-2249.2009.04033.x
Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330