BACKGROUND AND AIMS: There is a paucity of literature regarding the clinical profile of chronic pancreatitis (CP) in children. The aims of this retrospective study were to determine the etiology and clinical presentation, and to present our experience in diagnosing CP in children in China. METHODS: Clinical data of children who were treated for CP at Changhai Hospital from January 1997 to August 2006 were reviewed. RESULTS: A total of 427 CP patients presented to our center. There were 42 (9.8%) children with CP, including 21 males and 21 females, with a mean age of 11.7 years at the first onset. The main etiological factor was idiopathic (73.8%). Of the patients, 78.5% had episodes of mild to moderate abdominal pain and 54.8% had multiple (> or = 4) episodes. The mean duration of symptoms prior to the diagnosis was 41.6 months and a definite diagnosis was not made until 2 years later in 57.1% of these patients. The positive rates of ultrasound (US), computed tomography (CT) and magnetic resonance cholangiopancreatography (MRCP) (or magnetic resonance imaging [MRI]) for detecting ductal changes and intraductal stones or pancreatic calcification were 51.4% and 45.4%, 71.4% and 87.5%, 80.0% and 61.5%, respectively. CONCLUSION: The main etiological factor of Chinese children with CP is idiopathic. The main symptom in these patients is multiple episodes of mild to moderate abdominal pain, which often lead to a delay in the definite diagnosis. CT and MRCP (or MRI) should be used as the first investigation in the evaluation of these cases.
BACKGROUND AND AIMS: There is a paucity of literature regarding the clinical profile of chronic pancreatitis (CP) in children. The aims of this retrospective study were to determine the etiology and clinical presentation, and to present our experience in diagnosing CP in children in China. METHODS: Clinical data of children who were treated for CP at Changhai Hospital from January 1997 to August 2006 were reviewed. RESULTS: A total of 427 CP patients presented to our center. There were 42 (9.8%) children with CP, including 21 males and 21 females, with a mean age of 11.7 years at the first onset. The main etiological factor was idiopathic (73.8%). Of the patients, 78.5% had episodes of mild to moderate abdominal pain and 54.8% had multiple (> or = 4) episodes. The mean duration of symptoms prior to the diagnosis was 41.6 months and a definite diagnosis was not made until 2 years later in 57.1% of these patients. The positive rates of ultrasound (US), computed tomography (CT) and magnetic resonance cholangiopancreatography (MRCP) (or magnetic resonance imaging [MRI]) for detecting ductal changes and intraductal stones or pancreatic calcification were 51.4% and 45.4%, 71.4% and 87.5%, 80.0% and 61.5%, respectively. CONCLUSION: The main etiological factor of Chinese children with CP is idiopathic. The main symptom in these patients is multiple episodes of mild to moderate abdominal pain, which often lead to a delay in the definite diagnosis. CT and MRCP (or MRI) should be used as the first investigation in the evaluation of these cases.
Authors: Sarah J Schwarzenberg; Aliye Uc; Bridget Zimmerman; Michael Wilschanski; C Mel Wilcox; David C Whitcomb; Steven L Werlin; David Troendle; Gong Tang; Adam Slivka; Vikesh K Singh; Stuart Sherman; Uzma Shah; Bimaljit S Sandhu; Joseph Romagnuolo; Sue Rhee; John F Pohl; Emily R Perito; Chee Y Ooi; Jaimie D Nathan; Thiruvengadam Muniraj; Veronique D Morinville; Brian McFerron; Maria Mascarenhas; Asim Maqbool; Quin Liu; Tom K Lin; Michele Lewis; Sohail Z Husain; Ryan Himes; Melvin B Heyman; Nalini Guda; Tanja Gonska; Matthew J Giefer; Andres Gelrud; Cheryl E Gariepy; Timothy B Gardner; Steven D Freedman; Christopher E Forsmark; Douglas S Fishman; Gregory A Cote; Darwin Conwell; Randall E Brand; Melena Bellin; Bradley Barth; Peter A Banks; Michelle A Anderson; Stephen T Amann; Samer Alkaade; Maisam Abu-El-Haija; Judah N Abberbock; Mark E Lowe; Dhiraj Yadav Journal: J Pediatr Gastroenterol Nutr Date: 2019-04 Impact factor: 2.839
Authors: Aliye Uc; Emily R Perito; John F Pohl; Uzma Shah; Maisam Abu-El-Haija; Bradley Barth; Melena D Bellin; Kate M Ellery; Douglas S Fishman; Cheryl E Gariepy; Matthew J Giefer; Tanja Gonska; Melvin B Heyman; Ryan W Himes; Sohail Z Husain; Asim Maqbool; Maria R Mascarenhas; Brian A McFerron; Veronique D Morinville; Tom K Lin; Quin Y Liu; Jaimie D Nathan; Sue J Rhee; Chee Y Ooi; Zachary M Sellers; Sarah Jane Schwarzenberg; Jose Serrano; David M Troendle; Steven L Werlin; Michael Wilschanski; Yuhua Zheng; Ying Yuan; Mark E Lowe Journal: Pancreas Date: 2018 Nov/Dec Impact factor: 3.327
Authors: D Kohoutova; A Tringali; G Papparella; V Perri; I Boškoski; J Hamanaka; G Costamagna Journal: United European Gastroenterol J Date: 2018-12-05 Impact factor: 4.623
Authors: Ramit Mahajan; Ebby George Simon; Ashok Chacko; D Viswanath Reddy; P Rupesh Kalyan; A J Joseph; Amit Kumar Dutta; Sudipta Dhar Chowdhury; Reuben Thomas Kurien Journal: Indian J Gastroenterol Date: 2016-03-05
Authors: Veronique D Morinville; Mark E Lowe; Monika Ahuja; Bradley Barth; Melena D Bellin; Heather Davis; Peter R Durie; Brian Finley; Douglas S Fishman; Steven D Freedman; Cheryl E Gariepy; Matthew J Giefer; Tanja Gonska; Melvin B Heyman; Ryan Himes; Sohail Husain; Soma Kumar; Chee Y Ooi; John F Pohl; Sarah Jane Schwarzenberg; David Troendle; Steven L Werlin; Michael Wilschanski; Elizabeth Yen; Aliye Uc Journal: J Pediatr Gastroenterol Nutr Date: 2014-09 Impact factor: 2.839