Literature DB >> 19791734

Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient.

Midori Isobe1, Shingo Eikawa, Akiko Uenaka, Yoichi Nakamura, Tetsuo Kanda, Shigeru Kohno, Kiyotaka Kuzushima, Eiichi Nakayama.   

Abstract

We show correlation between strong and decreased NY-ESO-1-specific immunity with spontaneous regression and subsequent recurrence, respectively, in a long-surviving patient with an NY-ESO-1-expressing lung adenocarcinoma. An integrated immune response consisting of IgG antibody, as well as CD4 and CD8 T cells, against NY-ESO-1 was observed at the time of spontaneous regression of multiple pleural metastases. After tumor dormancy for 3 years, the tumor started to progress. IgG antibody levels and the number of CD4 and CD8 T cells against NY-ESO-1 decreased, but were still detectable. On the other hand, the number of Foxp3+ CD25 high T regulatory cells gradually increased. The findings suggest the relevance of the NY-ESO-1 immune response and its regulation by Foxp3+ CD25 high T regulatory cells in the clinical course of this lung cancer patient.

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Year:  2009        PMID： 19791734      PMCID： PMC2935771     

Source DB:  PubMed          Journal:  Cancer Immun        ISSN： 1424-9634


  33 in total

1.  Immunohistochemical analysis of NY-ESO-1 antigen expression in normal and malignant human tissues.

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Authors:  Y T Chen; M J Scanlan; U Sahin; O Türeci; A O Gure; S Tsang; B Williamson; E Stockert; M Pfreundschuh; L J Old
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3.  Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses.

Authors:  E Jäger; Y Nagata; S Gnjatic; H Wada; E Stockert; J Karbach; P R Dunbar; S Y Lee; A Jungbluth; D Jäger; M Arand; G Ritter; V Cerundolo; B Dupont; Y T Chen; L J Old; A Knuth
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

4.  Phenotypic analysis of antigen-specific T lymphocytes.

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Authors:  Ian D Davis; Weisan Chen; Heather Jackson; Phillip Parente; Mark Shackleton; Wendie Hopkins; Qiyuan Chen; Nektaria Dimopoulos; Tina Luke; Roger Murphy; Andrew M Scott; Eugene Maraskovsky; Grant McArthur; Duncan MacGregor; Sue Sturrock; Tsin Yee Tai; Simon Green; Andrew Cuthbertson; Darryl Maher; Lena Miloradovic; Susan V Mitchell; Gerd Ritter; Achim A Jungbluth; Yao-Tseng Chen; Sacha Gnjatic; Eric W Hoffman; Lloyd J Old; Jonathan S Cebon
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-13       Impact factor: 11.205

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Authors:  Sacha Gnjatic; Djordje Atanackovic; Elke Jäger; Mitsutoshi Matsuo; Annamalai Selvakumar; Nasser K Altorki; Robert G Maki; Bo Dupont; Gerd Ritter; Yao-Tseng Chen; Alexander Knuth; Lloyd J Old
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Journal:  Clin Cancer Res       Date:  2004-02-01       Impact factor: 12.531

10.  Identification of a unique antigen peptide pRL1 on BALB/c RL male 1 leukemia recognized by cytotoxic T lymphocytes and its relation to the Akt oncogene.

Authors:  A Uenaka; T Ono; T Akisawa; H Wada; T Yasuda; E Nakayama
Journal:  J Exp Med       Date:  1994-11-01       Impact factor: 14.307
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5.  Spontaneous Regression of Epithelioid Angiosarcoma in a Young Woman.

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Review 6.  Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives.

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  6 in total

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